The Role of Cytokines in the Regulation of Ferritin Expression
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 356)
Inflammation substantially alters iron metabolism. The plasma level of iron falls, along with that of transferrin. Conversely, the quantity of ferritin in the plasma increases by two- to three-fold, in many instances. Chronic inflammation, such as that which accompanies rheumatoid arthritis, for instance, is associated with a low-grade anemia. This “anemia of chronic disease” results, in part, from impaired delivery of iron to bone marrow normoblasts.
KeywordsToxicity Arthritis Ethyl Hydroxyl Superoxide
Robins-Browne, R. and J. Prpic, Effects of iron and desferrioxamine on infections with Yersinia enterocolitica
. Infection and Immunity, 1985. 47
: p. 774–779.PubMedGoogle Scholar
Bullen, J.J., et al.
, Hemochromatosis, iron and septicemia caused by Vibrio vulnificus
. Archives of Internal Medicine, 1991. 151
: p. 1606–1609.PubMedCrossRefGoogle Scholar
Windus, D., et al.
, Fatal Rhizopus infections in hemodialysis patients receiving deferoxamine
. Annals of Internal Medicine, 1987. 107
: p. 678–680.PubMedGoogle Scholar
Dinarello, C.A., Interleukin-1 and its related cytokines, in Macrophage-Derived Regulatory Factors
: Cytokines, C. Sorg, Editor. 1989, Karger: Basel. p. 105–154.Google Scholar
Torti, S., et al.
, The molecular cloning and characterisation of murine ferritin heavy chain, a tumor necrosis factor-induceable gene
. Journal of Biological Chemistry, 1988. 263
: p. 12638–126410.PubMedGoogle Scholar
Konijn, A., et al.
, Ferritin synthesis in inflammation; II. Mechanism of increased ferritin synthesis
. British Journal of Haematology, 1981. 49
: p. 361–370.PubMedCrossRefGoogle Scholar
Babior, B., Oxidants from phagocytes: Agents of defense and destruction
. Blood, 1984. 64
: p. 959–966.PubMedGoogle Scholar
Gutteridge J. and B. Halliwell Iron toxicity and oxygen radicals
. Balliere’s Clinical Hematology 1989. 2
p. 237Google Scholar
Klausner, R. and J. Harford, Cis-trans models for post-transcriptional gene regulation
. Science, 1989. 246
: p. 870–872.PubMedCrossRefGoogle Scholar
Leibold, E.A. and H.N. Munro, Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5’-untranslated region of ferritin heavy-and light-subunit mRNAs
. Proceedings of the National Academy of Science, 1988. 85
: p. 2171–2175.CrossRefGoogle Scholar
© Springer Science+Business Media New York 1994