The Role of Cytokines in the Regulation of Ferritin Expression

  • Jack Rogers
  • Linda Lacroix
  • Gerald Durmowitz
  • Kristen Kasschau
  • James Andriotakis
  • Kenneth R. Bridges
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 356)

Abstract

Inflammation substantially alters iron metabolism. The plasma level of iron falls, along with that of transferrin. Conversely, the quantity of ferritin in the plasma increases by two- to three-fold, in many instances. Chronic inflammation, such as that which accompanies rheumatoid arthritis, for instance, is associated with a low-grade anemia. This “anemia of chronic disease” results, in part, from impaired delivery of iron to bone marrow normoblasts.

Keywords

Toxicity Arthritis Ethyl Hydroxyl Superoxide 

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References

  1. 1.
    Robins-Browne, R. and J. Prpic, Effects of iron and desferrioxamine on infections with Yersinia enterocolitica. Infection and Immunity, 1985. 47: p. 774–779.PubMedGoogle Scholar
  2. 2.
    Bullen, J.J., et al., Hemochromatosis, iron and septicemia caused by Vibrio vulnificus. Archives of Internal Medicine, 1991. 151: p. 1606–1609.PubMedCrossRefGoogle Scholar
  3. 3.
    Windus, D., et al., Fatal Rhizopus infections in hemodialysis patients receiving deferoxamine. Annals of Internal Medicine, 1987. 107: p. 678–680.PubMedGoogle Scholar
  4. 4.
    Dinarello, C.A., Interleukin-1 and its related cytokines, in Macrophage-Derived Regulatory Factors: Cytokines, C. Sorg, Editor. 1989, Karger: Basel. p. 105–154.Google Scholar
  5. 5.
    Torti, S., et al., The molecular cloning and characterisation of murine ferritin heavy chain, a tumor necrosis factor-induceable gene. Journal of Biological Chemistry, 1988. 263: p. 12638–126410.PubMedGoogle Scholar
  6. 6.
    Konijn, A., et al., Ferritin synthesis in inflammation; II. Mechanism of increased ferritin synthesis. British Journal of Haematology, 1981. 49: p. 361–370.PubMedCrossRefGoogle Scholar
  7. 7.
    Babior, B., Oxidants from phagocytes: Agents of defense and destruction. Blood, 1984. 64: p. 959–966.PubMedGoogle Scholar
  8. 8.
    Gutteridge J. and B. Halliwell Iron toxicity and oxygen radicals. Balliere’s Clinical Hematology 1989. 2 p. 237Google Scholar
  9. 9.
    Klausner, R. and J. Harford, Cis-trans models for post-transcriptional gene regulation. Science, 1989. 246: p. 870–872.PubMedCrossRefGoogle Scholar
  10. 10.
    Leibold, E.A. and H.N. Munro, Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5’-untranslated region of ferritin heavy-and light-subunit mRNAs. Proceedings of the National Academy of Science, 1988. 85: p. 2171–2175.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jack Rogers
    • 1
  • Linda Lacroix
    • 1
  • Gerald Durmowitz
    • 1
  • Kristen Kasschau
    • 1
  • James Andriotakis
    • 1
  • Kenneth R. Bridges
    • 1
  1. 1.Hematology Division, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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