Abstract
Mucosal surfaces provide the portal of entry for most pathogenic microorganisms. In protection the mammalian host has concentrated a number of defense factors in the exocrine secretions that bathe mucosal surfaces. Understanding how these factors operate to prevent pathologic consequences of microbial challenge and what mechanisms a pathogen uses to evade this host defense is essential to the development of interventive approaches. Lactoferrin (LF) and secretory IgA (slgA) are both secreted in significant quantities at most mucosal surfaces and in milk. Both of these factors are reported to have bacteriostatic activity (1–8) and interact with each other and other defense factors (including lysozyme, complement, and lactoperoxidase) to modify their effectiveness (9, 10). In addition purified iron-free LF has been shown to have microbicidal activity against a variety of bacteria and yeast via mechanisms that are not reversed by the addition of free iron (11–16). A factor present in many commercial LF-enriched preparations, which co-purifies with slgA, has been reported to result in syner-gistic bactericidal activity and these impure LF preparations are able to kill bacterial strains that are resistant to purified LF (17).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
A.B. Otnaess and I. Orstavik, Infect. Immun. 33, 459, (1981).
E. Weinberg, Science 184, 952 (1974).
J.J. Bullen, H.J. Rogers and E. Griffiths, Curr. Top. Microbiol. Immun., 80, 1, (1978).
J.M. Dolby and P. Hoover, J. Hyg. (Camb). 83, 255, (1979).
H.J. Rogers, Immunology, 30, 425, (1976).
J.M. Dolby and S. Stephens, Acta Paediatr. Scand., 72, 577, (1983).
J. Bullen, H. Rogers, L. Leigh, Brit. Med. J., 1, 69, (1972).
G. Spik, A. Cheron, J. Montreuil and J. Dolby, Immunology 35, 663, (1978).
C.P. Thompson, B.M. McCarty, N.D. Chasteen, Biochim. Biophys. Acta 22, 530, (1986).
E. Ainscough, A. Brodie, J. Plowman, S. Bloor, J. Loehr and T. Loehr, Biochemistry, 19, 4072, (1980).
R. Arnold, J. Russell, W. Champion and J. Gauthier, Infect. Immun., 32, 655, (1981).
R.R. Arnold, M.F. Cole and J.R. McGhee, Science, 197, 263, (1977).
R.R. Arnold, J.E. Russell, W.J. Champion, M. Brewer and J.L. Gauthier, Infect. Immun., 35, 792, (1982).
J.R. Kalmar and R.R. Arnold. Infect. Immun. 56, 2552, (1982).
C.A. Bortner, R.D. Miller and R.R. Arnold. Infect. Immun. 51, 373, (1986).
C.A. Bortner, R.R. Arnold and R.D. Miller. Can. J. Microbiol. 35, 1048, (1989).
M.A. Motley and R.R. Arnold, in Recent Advances in Mucosal Immunology, J. Mestecky, J.R. McGhee, J. Bienenstock and P.L. Ogra, Eds. (Plenum Publishing Corp., 1987), Park A, pp. 591-599.
R.R. Arnold, J.E. Russell, S.M. Devine, M. Adamson and K.M. Pruitt, in Cariolog Today. Int. Congr., Zurich, B. Guggenhein, Eds., (Karger, Basel, 1984), 75.
R.M. Broekhuyse, Invest. Opthalmol. 13, 550, (1974).
T. Watanabe, H. Nagura, K. Watanabe and W.R. Brown, FEBS Lett. 168, 203 (1984).
L. Bläckberg and O. Hernell, FEBS Lett., 109, 180, (1980).
A. Hekman, Biochim. Biophys. Acta., 251, 380, (1971).
P.L. Masson, La Lactoferrine. Proteine des Secretions Externes et des Leucocytes Neutrophiles, Arsica, Bruxelles, 1970.
T.K. Roberts and B. Boettcher, J. Reprod. Fertil., 18, 347, (1969).
P.L. Masson and J.F. Heremans, Eur. J. Biochem., 6, 579, (1968).
B. Reiter, J.H. Brock and E.D. Steel, Immunology, 28, 83, (1975).
E. Griffiths and J. Humphreys, Infect. Immun., 15, 396, (1977).
S. Stephens, J.M. Dolby, J. Montreuil and G. Spik, Immunology, 41, 597 (1980).
M.S. Blake, K.H. Johnston, G.J. Russell-Jones and E.C. Gotschlich, Anal. Biochem, 136, 1715, (1984).
S. Hamada and H.D. Slade, Microbiol. Rev., 44, 331, (1980).
J. Mestecky, J.R. MeGbee, R.R. Arnold, S.M. Michalek, S.J. Prince and J.L. Babb, J. Clin. Invest., 61, 731,(1978).
S. Ahlstedt, B. Carlsson, S.P. Fällström, L.A. Hanson, J. Holmgren, G.Lidin-Janson, B.S. Lindblad, U. Jopdal, B. Kaijser, A. Sohl-Äkerlund and C. Wadsworth, Ciba Found. Synp. 46, Excerpta Medica, Amsterdam, (1977).
R.M. Goldblum, S. Ahlstedt, BN. Carlsson, L.A. Hanson, J. Jodal, G. Lidin-Janson and A. Sohl, Nature, 257, 797, (1975).
R.C. Montgomery, B.R. Rosner and J. Cohn, Immun. Comm., 3, 143, (1974).
S.S. Ogra, D. Weintraub and P.L. Ogra, Adv. Exp. Med. Biol., 107, 95, (1978).
H.L. Arnos and E. Taylor, J. Exp. Med., 25, 507, (1917).
C.G. Bull and C.M. McKee, Am. J. Hyg., 9, 490, (1929).
R.D. Rossen, J.A. Kasel and R.B. Couch, Prog. Med. Virol., 13, 194, (1971).
J. Holmgren, A.-M. Svennerholm, O. Ouchterlony, A., Anderson, G. Wallerström and U. Westerberg-Berndtsson, Infect. Immun., 12, 1331–1340, (1975).
E.S. Fubara and R. Fréter, J. Immunol., 111, 395, (1973).
L.A. Hanson, S. Ahlstedt, B. Carlsson, B. Kaijser, P. Larsson, I. Mattsby-Baltzer, A. Sohl-Åkerlund, C. Svanborg-Eden and A.-M. Svennerholm, Adv. Exp. Med. Biol., 107, 165, (1978).
J. Mestecky, J.R. McGhee, S.M. Michalek, R.R. Arnold, S.S. Crago and J.L. Babb, Adv. Exp. Med. Biol., 107, 185, (1978).
M.J. Parmley and A.E. Beer, J. Diary Sci., 60, 655, (1977).
T.W. Hutchens, J.F. Henry, and T.-T. Yip. Proc. Natl. Acad. Sci. U.S.A. 88, 2994, (1991).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Akin, D.T., Lu, M.Q., Lu, S.J., Kendall, S., Rundegren, J., Arnold, R.R. (1994). Bactericidal Activity of Different Forms of Lactoferrin. In: Hutchens, T.W., Rumball, S.V., Lönnerdal, B. (eds) Lactoferrin. Advances in, Experimental Medicine and Biology, vol 357. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2548-6_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2548-6_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6087-2
Online ISBN: 978-1-4615-2548-6
eBook Packages: Springer Book Archive