Cortical Dysgenesis in Adults with Epilepsy
Gross cortical dysgenesis (CD) is a well-recognised cause of epilepsy. Affected patients present with epilepsy in infancy or early childhood, are often severely mentally handicapped, and more often than not exhibit bilateral motor deficits. Recently, subtle forms of CD have been identified in adults with previously designated cryptogenic epilepsy (Raymond et al., 1992, 1993). Unlike children with CD, affected adults may have normal intelligence and rarely exhibit fixed neurological signs.
KeywordsMigration Germinal Neurol Polyhydramnios Lissencephaly
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- Andermann, F., Olivier, A, Melanson, D., and Robitaille, Y., 1989, Epilepsy due to focal cortical dysplasia with macrogyria and the forme fruste of tuberous sclerosis: a study of 15 patients, in: “Advances in Epileptology” Vol. 16, P. Wolf, M. Dam, D. Janz, F. E. Dreifuss, FE, eds, Raven Press, New York.Google Scholar
- Raymond, A. A., Fish, D. R., Cook, M. J., Sander, J. W. A. S., and Shorvon, S. D., 1992, Adult patients with cortical dysgenesis and epilepsy, Epilepsia (suppl 3); 33: 74–75 (abstr).Google Scholar
- Raymond, A. A., Halpin, S. F. S., Alsanjari, N. et al., 1994, Dysembryoplastic neuroepithelial tumour: features in 16 patients, Brain; in press.Google Scholar
- Stefansson, K., Wollmann, R., and Huttenlocher, P., 1988, Lineages of cells in the central nervous system, in: “Tuberous Sclerosis,” M. Gomez, ed., 2nd ed, Raven Press, New York.Google Scholar