From Voltammetry to Industrial Plant: Electrochemical Synthesis of DL-Homocysteine from DL-Homocystine — An Example of Scale-Up

  • Gaspar Sánchez-Cano
  • Vicente Montiel
  • Vicente García
  • Antonio Aldaz
  • Eduardo Elías

Abstract

An industrial process for the electrochemical synthesis of DL-Homocysteine from DL-Homocystine is described. DL-Homocysteine is a key intermediate for the synthesis of Citiolone (a powerful agent used to treat bronchitis and nasal catarrh). The work starts with a fundamental study, the voltammetric behaviour of DL-Homocystine, followed by a laboratory and pilot plant study and finishes with the development of an industrial process (30 tons/year of DL-Homocistine electroreduced). The method avoids the use of hazardous and polluting reductants such as Zn/H+. The figures of merit are a material yield of 95%, production over 200kg/m2day and a energy cost less than 2 kWh/kg.

Keywords

Zinc Cysteine Chlorine Hydrochloride Disulfide 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Gaspar Sánchez-Cano
    • 1
  • Vicente Montiel
    • 1
  • Vicente García
    • 1
  • Antonio Aldaz
    • 1
  • Eduardo Elías
    • 2
  1. 1.Departamento de Química FísicaUniversidad de AlicanteAlicanteSpain
  2. 2.Prodesfarma SA (D.M.P.)Sant CeloniSpain

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