In Utero Exposure to Carbamazepine Effects on the Fetus

  • Elisabeth Robert
  • Bengt Källén

Abstract

Carbamazepine (CBZ) is an iminostilbene with a tricyclic structure. It has been in clinical use for more then twenty years and has often been considered the anticonvulsant of choice for women with seizure disorders who wish to have a pregnancy. This was based on small series of exposed women. Recently, Morrison and Rieder (1993) made a survey of the usual practice among Canadian neurologists with respect to the management of epilepsy during pregnancy. In a majority (75%) CBZ was mentioned as the drug of choice. Epidemiological studies published during the past five years indicate an increased risk for some adverse reproductive outcome, however.

Keywords

Folate Neurol Epoxide Monit Hydrolase 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Elisabeth Robert
    • 1
  • Bengt Källén
    • 2
  1. 1.Institut Européen des GénomutationsLyonFrance
  2. 2.Tornblad InstituteUniversity of LundLundSweden

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