Complement and Antibody Enhance Binding and Uptake of HIV-1 by Bone Marrow Cells

  • Bart A. van de Wiel
  • Leendert J. Bakker
  • Loek de Graaf
  • Roel A. de Weger
  • Jan Verhoef
  • Jan G. van den Tweel
  • Piet Joling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 355)

Abstract

Infection of bone marrow cells by HIV-1 might be a principle cause for the bone marrow myelodysplasia and peripheral blood cytopenias in HIV-1 infected patients1. Infection of immature cells in bone marrow may have long-lasting effects on the haematopoiesis2. Although the CD4 molecule is considered as the major receptor of HIV-1, also other factors may be decisive for binding and modulation of the retrovirus3-5. In this study we present data of the binding and the infection of bone marrow cells by HIV-1. Furthermore the role of anti-HIV-1 antibody and complement on binding of HIV-1 is evaluated.

Keywords

Heparin Paraformaldehyde Fluorescein FITC Isothiocyanate 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Bart A. van de Wiel
    • 1
  • Leendert J. Bakker
    • 2
  • Loek de Graaf
    • 2
  • Roel A. de Weger
    • 1
  • Jan Verhoef
    • 2
  • Jan G. van den Tweel
    • 1
  • Piet Joling
    • 1
  1. 1.Departments of PathologyThe Netherlands
  2. 2.Clinical Microbiology University HospitalThe Netherlands

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