Complement and Antibody Enhance Binding and Uptake of HIV-1 by Bone Marrow Cells
Infection of bone marrow cells by HIV-1 might be a principle cause for the bone marrow myelodysplasia and peripheral blood cytopenias in HIV-1 infected patients1. Infection of immature cells in bone marrow may have long-lasting effects on the haematopoiesis2. Although the CD4 molecule is considered as the major receptor of HIV-1, also other factors may be decisive for binding and modulation of the retrovirus3-5. In this study we present data of the binding and the infection of bone marrow cells by HIV-1. Furthermore the role of anti-HIV-1 antibody and complement on binding of HIV-1 is evaluated.
KeywordsHuman Immunodeficiency Virus Type Bone Marrow Cell Follicular Dendritic Cell Conventional Transmission Electron Microscopy Fresh Serum
Unable to display preview. Download preview PDF.
- 11.C.F. Ebenbichler, N.M. Thielens, R. Vornhagen, P. Marschang, G.J. Arlaud, and M.P. Dierich, Human immunodeficiency virus type 1 activates the classical pathway of complement by direct Cl binding through specific sites in the transmembrane glycoprotein gp41, J. Exp. Med. 174:1417(1991).PubMedCrossRefGoogle Scholar