Complement and Antibody Enhance Binding and Uptake of HIV-1 by Bone Marrow Cells
Infection of bone marrow cells by HIV-1 might be a principle cause for the bone marrow myelodysplasia and peripheral blood cytopenias in HIV-1 infected patients1. Infection of immature cells in bone marrow may have long-lasting effects on the haematopoiesis2. Although the CD4 molecule is considered as the major receptor of HIV-1, also other factors may be decisive for binding and modulation of the retrovirus3-5. In this study we present data of the binding and the infection of bone marrow cells by HIV-1. Furthermore the role of anti-HIV-1 antibody and complement on binding of HIV-1 is evaluated.
KeywordsHeparin Paraformaldehyde Fluorescein FITC Isothiocyanate
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