Abstract
Intercellular adhesion molecule 1 (ICAM-1; CD54) is an adhesion molecule, that participates in a variety of cell-cell adhesion phenomena1. It serves as a ligand for the leucocyte integrins LFA-1 and Mac-1 2,3 and as a receptor for different pathogens4,5. ICAM-1 is constitutively expressed in vivo on cells of the high endothelial venules and on germinal centre cells in lymph node6,7, whereas its expression is readily induced on leucocytes and different types of adherent cells. ICAM-1 is especially present in areas of inflammation, where its expression of mRNA and protein has been induced by inflammatory mediators, such as lipopolysaccharide, IFNγ, IL-1 and , TNF8.
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References
Hogg, N., P.A. Bates, and J. Harvey. 1991. Structure and function of intercellular adhesion molecule-1. In: Chemical Immunology Vol 50; Integrins and ICAM-1 in immune responses. Eds. K. Ishizaka, P.J. Lachmann, B.H. Waksman. Karger, Basel, pp 98.
Marlin, S.D., and T. A. Springer. 1987. Purified intercellular adhesion molecule-1 (ICAM-1) a ligand for lymphocyte function-associated antigen-1 (LFA-1). Cell 51:813.
Diamond M.S., D.E. Staunton, S.D. Marlin, and T.A. Springer 1991. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (cd54) and its regulation by glycosylation. Cell Biol. 111:3129.
Greve, J.M., G. Davis, A.M. Meyer, C.P. Forte, S.C. Yost, C.W. Marlor, M.E. Kamarck, and A. McClelland. 1989. The major human rhinovirus receptor is ICAM-1. Cell 56:839.
Berendt, A.R., D.L. Simmons, J. Tansey, C.I. Newbold, and K. Marsh. 1989. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341:57.
Holzmann, B., J.M. Lehmann, H.W. Ziegler-Heitbrock, I. Funke, G. Riethmüller, and J.P. Johnson. 1988. Glycoprotein P3.58, associated with tumour progression in malignant melanoma, is a novel leucocyte activation antigen. Int. J. Cancer 41:542–547.
Dustin, M.L., R. Rothlein, A.K. Bahn. C.A. Dinarello, and T.A. Springer. 1986. Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245.
Rothlein R., M. Czajkowski, and T.K. Kishimoto. 1991. Intercellular adhesion molecule-1 in the inflammatory response. In: Chemical Immunology Vol 50; Integrals and ICAM-1 in immune responses. Eds. K. Ishizaka, P.J. Lachmann, B.H. Waksman. Karger, Basel, pp 135.
Liu, Y-J., G.D. Johnson, J. Gordon, and I.C.M. MacLennan. 1992. Germinal centres in T-cell-dependent antibody responses. Immunol. Today 13:17.
Koopman, G., H.K. Parmentier, H-J. Schuurman, W. Newman, C.J.L.M. Meijer, and S.T. Pals. 1991. J. Exp. Med. 173:1297.
Johnson, J.P., B.G. Stade, U. Hupke, B. Holzmann, and G. Riethmüller. 1988. The melanoma progression-associated antigen P3.58 is identical to the intercellular adhesion molecule, ICAM-1. Immunobiol. 178:275.
Bloemen, P., G. Moldenhauer, M. Van Dijk, H-J. Schuurman, and A.C. Bloem. 1992. Multiple ICAM-1 (CD54) epitopes are involved in homotypic B-cell adhesion. Scand. J. Immunol. 35:517.
Ahsmann, E.J.M., H.M. Lokhorst, A.W. Dekker, and A.C. Bloem. 1992. Lymphocyte-associated antigen-1 expression on plasma cells correlates with tumor growth in multiple myeloma. Blood 79:2068.
Parmentier H.K., J.A. van der Linden, J. Krijnen, D.F. van Wichen, L.H.P.M. Rademakers, A.C. Bloem, and H.-J. Schuurman. 1991. Human follicular dendritic cells: isolation and characteristics in situ and in suspension. Scand. J. Immunol. 33:441.
Joling, P., S. Boom, J. Johnson, M.E.M. Dekker, J.G. van Den Tweel, H-J. Schuurman, and A.C. Bloem. 1993. Domain 5 of ICAM-1 is involved in adhesion of B lymphocytes and follicular dendritic cells. J. Immunol. submitted for publication.
Mölgg M., W. Schwaeble, J.P. Johnson, M.P. Dierich. 1991. Generation of recombinant, carbohydrate-free intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 fragments in Escherichia coli and mapping of epitopes recognized by anti-ICAM-1 monoclonal antibodies. Immunol. Lett., 28:237.
Schriever F., A.S. Freedman, G. Freeman, E. Messner, G. Lee, J. Daley, and L.M. Nadler. 1989. Isolated human Follicular Dendritic Cells display a unique antigenic phenotype. J. Exp. Med. 169:2043.
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Joling, P. et al. (1994). Domain 5 of the Intercellular Adhesion Molecule-1 (Icam-1) is Involved in Adhesion of B-Cells and Follicular Dendritic Cells. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_22
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_22
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