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In Vivo GP39-CD40 Interactions Occur in the Non-Follicular Compartments of the Spleen and are Essential for Thymus Dependent Antibody Responses and Germinal Center Formation

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In Vivo Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 355))

Abstract

The initiation of thymus-dependent (TD) antibody responses requires class ll-restricted antigen-specific helper T cell cognate interactions with B cells. None of the molecularly cloned cytokines, alone or in combination, can replace the contact-dependent requirement for B cell activation1. The molecule which mediates the contact-dependent signal is a 39 kD membrane protein which is expressed on the surface of activated T-helper (Th) cells2,3. This membrane protein, gp39, was identified as the ligand for the B cell membrane protein CD40. CD40, a mitogenic receptor expressed on all mature B lymphocytes4, is a type I membrane protein and member of the TNF receptor family5. Evidence that CD40 is an important receptor on B cells is derived from studies that anti-CD40 mAb and cofactors such as anti-immunoglobulin (Ig) and cytokines initiate both B cell growth and differentiation6,7.

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Authors and Affiliations

  1. Dept. Immunology and Medical Microbiology, TNO-MBL, POB 5815, 2280, HV, Rijswijk, The Netherlands

    A. J. M. van den Eertwegh, M. Vanneurs, W. J. A. Boersma & E. Claassen

  2. Dept. of Microbiology Dartmouth School, One Medical Center drive, Lebanon, NH, 03757, USA

    T. M. Foy & R. J. Noelle

Authors
  1. A. J. M. van den Eertwegh
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  2. M. Vanneurs
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  3. T. M. Foy
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  4. R. J. Noelle
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  5. W. J. A. Boersma
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  6. E. Claassen
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Editor information

Editors and Affiliations

  1. University of Liège, Liège, Belgium

    E. Heinen , M. P. Defresne , J. Boniver  & V. Geenen , ,  & 

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van den Eertwegh, A.J.M., Vanneurs, M., Foy, T.M., Noelle, R.J., Boersma, W.J.A., Claassen, E. (1994). In Vivo GP39-CD40 Interactions Occur in the Non-Follicular Compartments of the Spleen and are Essential for Thymus Dependent Antibody Responses and Germinal Center Formation. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_13

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  • DOI: https://doi.org/10.1007/978-1-4615-2492-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6062-9

  • Online ISBN: 978-1-4615-2492-2

  • eBook Packages: Springer Book Archive

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