Clinical Manifestations and Therapy of Hepatic Encephalopathy

  • Juan Rodés
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 341)

Abstract

Hepatic encephalopathy (HE) is a functional and generally reversible alteration of the central nervous system that appears in patients with acute and chronic liver disease. The pathogenesis of HE is not well understood (this aspect is deeply discussed in another chapter of this issue) although it has been suggested that the key mechanism is due to the inability of the liver to eliminate endogen and exogen products which are toxic to the brain. These substances reach the systemic blood stream because of the presence of hepatic failure, and the development of portosystemic shunts. Both mechanisms allow the intestinal blood to reach the brain without being cleared by the liver (1).

Keywords

Hepatitis Depression Meningitis Bismuth Constipation 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Juan Rodés
    • 1
  1. 1.Liver Unit, Hospital Clínico y ProvincialUniversity of BarcelonaSpain

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