Effect of Acute and Chronic Administration of Ethanol on c-fos Expression in Brain
Trans-synaptic activation of neurons occurs over a time frame ranging from milliseconds to hours. Recently, it has been shown that the slower long-term responses, which are thought to underlie neuronal plasticity, are associated with induction of gene expression. The genes involved fall into two major groups: the cellular immediate early genes (IEGs), where transcription is activated rapidly and transiently within minutes of stimulation (Greenberg et al, 1985; Morgan and Curran, 1986) and the late response genes, where expression is induced more slowly over a period of hours (Merlie et al., 1984; Castelluci et al., 1988).
KeywordsDMSO Adenosine Caffeine NMDA Diazepam
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- Lundquist, F., 1959, The determination of ethyl alcohol in blood and tissues, Meth Biochem Anal. 7: 215Google Scholar
- Mönier, H., Sieghart, W., Richards, J.G., and Hunkelev, W., 1984, Photo-affinity labelling of benzodiazepine receptors with a partial inverse agonist, Eur J Pharmacol. 102: 181.Google Scholar
- Morgan, P.F., Nadi, N.S., Karanian, J. and Linnoila, M., 1992, Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors, Eur J Pharmacol. 255: 217.Google Scholar
- Morrow, A.L., Suzdak, P.D., Karanian, J.W. and Paul, S.M., 1988, Chronic ethanol administration alters GABA, pentobarbital and ethanol mediated 36Cl- uptake in cerebral cortical synaptoneurosomes, J Pharm Exp Ther. 246: 158.Google Scholar
- Wilson, M.C. and Higgins, G.A., 1989, In Situ Hybridisation, in “Neuromethods: Molecular Neurobiological Techniques”, Vol 16, A.A. Boulton, G.B. Baker and A.T. Campagnoni, eds., Humana Press, New Jersey.Google Scholar