Advertisement

Effects of Acute and Chronic Ethanol Administration on the Poly-Phosphoinositide Signaling Activity in Brain

  • Grace Y. Sun
  • Jian-ping Zhang
  • Tai-An Lin

Abstract

Ethanol ingestion is known to exert diverse physiological effects on many body organs including the central nervous system (CNS). While excess acute ethanol intake can result in sedation, chronic ingestion is associated with development of tolerance and physical dependence and in turn, this may lead to the manifestation of withdrawal hyperexcitability. The biochemical mechanisms underlying the effects of ethanol are not well understood although alterations of many cell surface processes including membrane transport enzymes, receptors and ion channel activities have been implicated (see review by Deitrich et al., 1989). Some of these effects may be due partly to ethanol’s ability to disorder membrane lipids, resulting in an alteration of the intricate relationship between proteins and lipids within the membrane. However, it is clear that ethanol does not act globally on the membrane lipids, rather, changes are attributed to the effects of ethanol on specific types of lipids present in different membrane domains (Wood and Schroeder, 1988). In order to better understand the physiological manifestations related to acute and chronic ethanol ingestion, it is important first to identify the ethanol-sensitive biochemical mechanisms in brain and then followed by attempts to understand how adaptation to the changes is developed.

Keywords

Inositol Phosphate Chronic Ethanol Ethanol Administration Acute Ethanol Ethanol Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alling C., Hansson E. and Simonsson P., 1989, Cell cultures as a model for alcohol research. In “Molecular Mechanisms of Alcohol: Neurobiology and Metabolism” Sun et al., eds., Humana Press, Clifton, NJ. p193–206.Google Scholar
  2. Allison J.H. and Cicero T.J., 1980, Alcohol acutely depresses myo-inositol 1-phosphate levels in the male rat cerebral cortex. J. Pharmacol. Exp. Therap, 213: 24–27.Google Scholar
  3. Atack J.R., Cook S.M., Watt A.P. and Ragan C.I., 1992, Measurement of lithium-induced changes in mouse inositol(1)phosphate levels in vivo. J. Neurochem., 59: 1946–1954.PubMedCrossRefGoogle Scholar
  4. Berridge, M.J., 1987, Inositol trisphosphate and diacylglycerol: Two interacting second messengers. Ann. Rev. Biochem., 56: 159–193.PubMedCrossRefGoogle Scholar
  5. Bredt D.S., Mourey R.J. and Snyder S.H., 1989, A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues. Biochem. Biophys. Res. Comm., 159: 976–982.PubMedCrossRefGoogle Scholar
  6. Chandrasekhar, R., Lin, T-N, and Sun, G.Y., 1988a, Labeling of rat brain phospholipids by [32P]-ATP: effects of chronic ethanol administration, in “Biomedical and Social Aspects of Alcohol and Alcoholism,” K. Kuriyama, A. Tanaker and H. Ishic, eds., Excerpta Medica, International Congress Series 805, pp. 295–298.Google Scholar
  7. Chandrasekhar, R., Huang, H-M. and Sun, G.Y., 1988b, Alterations in rat brain polyphosphoinositide metabolism due to acute ethanol administration. J. Pharmacol. Exp. Ther., 245: 120–123.PubMedGoogle Scholar
  8. Deitrich R.A., DunwiddieT.V., Harris R.A. and Erwin V.G., 1989, Mechanism of action of ethanol: Initial central nervous system actions. Pharm. Rev., 41: 489–537.PubMedGoogle Scholar
  9. Erickson C.K. and Graham D.T., 1973, Alterations of cortical and reticular acetylcholine release by ethanol in vivo. J. Pharmacol. Exp. Ther., 185: 583–593.PubMedGoogle Scholar
  10. Fowler C.J. and Tiger G., 1991, Modulation of receptor-mediated inositol phospholipid breakdown in the brain. Neurochem. Int., 19: 171–206.CrossRefGoogle Scholar
  11. Gonzales R.A. and Crews F.T., 1988, Effects of ethanol in vivo and in vitro on stimulated phosphoinositide hydrolysis in rat cortex and cerebellum. Alcoholism: Clin. Exp. Res., 12: 94–98.CrossRefGoogle Scholar
  12. Gonzales R.A., Theiss C. and Crews, F.T., 1986, Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain. J. Pharmacol. Exp. Ther., 237: 92–98.PubMedGoogle Scholar
  13. Hoek J.B. and Taraschi T.F., 1988, Cellular adaptation to ethanol. TIBS, 13: 269–274.PubMedGoogle Scholar
  14. Hoek J.B., Thomas A.P., Rubin R. and Rubin E., 1987, Ethanol-induced mobilization of calcium by activation of phosphoinositide-specificphospholipase C in intact hepatocytes. J. Biol. Chem., 262: 682–691.PubMedGoogle Scholar
  15. Hoek J.B., Thomas A.P., Rooney T.A., Higashi K. and Rubin E., 1992, Ethanol and signal transduction in the liver. FASEB J., 6, 2386–2396.PubMedGoogle Scholar
  16. Hoffman P.L. and Tabakoff B., 1990, Ethanol and guanine nucleotide binding proteins: a selective interaction. FESEB J., 4, 2612–2622.Google Scholar
  17. Hoffman P.L., Moses F., Luthin G.R. and Tabakoff B., 1986, Acute and chronic effects of ethanol on receptor-mediated phosphoinositol 4, 5-bisphosphate breakdown in mouse brain. Mol. Pharmacol., 30: 13–18.PubMedGoogle Scholar
  18. Lee S.Y., Sim S.S., Kim J.W., Moon K.H., Kim J.H., Rhee S.G., 1990, Purification and properties of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain. J. Biol. Chem., 265: 9434–9440.PubMedGoogle Scholar
  19. Lin T.A., Lin T-N., He Y.Y., Hsu C.Y., and Sun G.Y., 1992, Effects of focal cerebral ischemia on inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities in rat cortex. Biochem. Biophys. Res. Commun., 184: 871–877.PubMedCrossRefGoogle Scholar
  20. Lin T.A., Lin T-N., He Y.Y., Hsu C.Y., and Sun G.Y., 1992, Effects of focal cerebral ischemia on inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities in rat cortex. Biochem. Biophys. Res. Commun., 184: 871–877.PubMedCrossRefGoogle Scholar
  21. Rabin R.A., Wolfe B.B., Dibner M.D., Zahniser N.R., Melchior C.L. and Molinoff P.B., 1980, Effects of ethanol administration and withdrawal on neurotransmitter receptor systems in C57BL mice. J. Pharmacol. Exp. Ther., 213: 491–496.PubMedGoogle Scholar
  22. Rubin T. and Hoek J.B., 1988, Ethanol-induced stimulation of phosphoinositide turnover and calcium influx in isolated hepatocytes. Biochem. Pharmacol., 37: 2461–2466.PubMedCrossRefGoogle Scholar
  23. Ritchie T., Kim H-S., Cole R., deVellis J., and Noble E.P., 1988, Alchol-induced alterations in phosphoinositide hydrolysis in astrocytes. Alcohol, 5: 183–187.PubMedCrossRefGoogle Scholar
  24. Sherman W.R., Munsell L.Y., Gish B.G. and Honchan M.P., 1985, The effect of systemic administration of lithium on phosphoinositide metabolism in rat brain kidney and testis. J. Neurochem. 44: 798–807.PubMedCrossRefGoogle Scholar
  25. Simonsson P., Hansson, E., Alling C., 1989a, Ethanol potentiates serotonin stimulated inositol lipid metabolism in primary astroglial cell cultures. Biochem. Pharmacol., 38: 2801–2805.PubMedCrossRefGoogle Scholar
  26. Simonsson P., Sun G.Y., Vecsei L. and Alling C., 1989b, Ethanol effects on bradykinin-stimulated phosphoinositide hydrolysis in NG 108-15 neuroblastoma-glioma cells. CellSignalling, 6: 475–479.Google Scholar
  27. Smith T.L., 1983, Influence of chronic ethanol consumption on muscarinic cholinergic receptors and their linkage to phospholipid metabolism in mouse synaptosomes. Life Sci., 22: 661–663.Google Scholar
  28. Smith T.L., 1990, The effects of acute exposure to ethanol on neurotensin and guanine nucleotide-stimulation of phospholipase C activity in intact NIE-115 neuroblastoma cells. Life Sci., 47: 115–119.Google Scholar
  29. Smith T.L., Yamamura H.I. and Lee L., 1986, Effect of ethanol on receptor-stimulated phosphatidic acid and polyphosphoinositide metabolism in mouse brain. Life Sci., 39: 1675–1684.PubMedCrossRefGoogle Scholar
  30. Sun, G.Y. and Sun, A.Y., 1983, Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes. Biochem. Biophys. Res. Commun., 113: 262–268.PubMedCrossRefGoogle Scholar
  31. Sun, G.Y. and Sun, A.Y., 1985, Ethanol and membrane lipids. Alcoholism: Clin. Exp. Res., 9: 164–180.CrossRefGoogle Scholar
  32. Sun, G.Y. and Lin, T-N., 1989, Time course for labeling of brain membrane phosphoinositides and other phospholipids after intracerebral injection of [32P]-ATP. Evaluation by an improved HPTLC method. Life Sci., 44: 689–696.PubMedCrossRefGoogle Scholar
  33. Sun, G.Y. and Lin T.N., 1990, Dynamic turnover of mouse brain phospholipids during normal aging and response to ischemia. Upsala J. Med. Sci. (Suppl), 48: 209–218.Google Scholar
  34. Sun, G.Y., Huang, H-M., Lee, D-Z. and Sun, A.Y., 1984, Increased acidic phospholipids in rat brain membranes after chronic ethanol administration. Life Sci., 35: 2127–2133.PubMedCrossRefGoogle Scholar
  35. Sun, G.Y., Huang, H-M., Chandrasekhar, R., Lee, D.Z. and Sun, A.Y., 1987a, Effects of chronic ethanol administration on rat brain phospholipid metabolism. J. Neurochem., 48: 974–980.PubMedCrossRefGoogle Scholar
  36. Sun, G.Y., Huang, H-M., Lee, D-Z., Chung-Wang, Y-J., Wood, W.G., Strong, R. and Sun, A.Y., 1987b, Chronic ethanol effect on the acidic phospholipids of synaptosomes isolated from cerebral cortex of C57BL/6NNIA mice-a comparison with age. Alcohol and Alcoholism, 22: 367–373.PubMedGoogle Scholar
  37. Sun, G.Y., Chandrasekhar, R. and Huang, H-M., 1989a, Effects of acute and chronic ethanol administration on metabolism of brain acidic phospholipids. In “Molecular Mechanisms of Alcohol”, Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, Y.H. and Sun, A.Y., eds., Humana Press, Clifton, New Jersey, pp 15–38.CrossRefGoogle Scholar
  38. Sun G.Y., Yoa F-G. and Lin T-N., 1990, Degradation of poly-phosphoinositides in brain subcellular membranes in response to decapitation insult. Neurochem. Int., 17: 529–535.PubMedCrossRefGoogle Scholar
  39. Sun G.Y., Navidi M., Yoa F.G. and Lin T.N., 1991, Effects of acute and chronic ethanol administration on phosphoinositide metabolism in mouse brain. Alcohol and Alcoholism (Suppl 1), p215–219.Google Scholar
  40. Sun, G.Y., Navidi M., Yoa F.G., Lin T.N., Orth O.E., Stubbs E.B. and MacQuarrie R.A., 1992, Lithium effects on inositol phosphate and inositol phospholipids in rat brain: studies with radiotracer technique and ion chromatography. J. Neurochem., 58: 290–297.PubMedCrossRefGoogle Scholar
  41. Sun, G.Y., Navidi, M., Yoa, F-G., Wood, W.G., and Sun, A.Y., 1993, Effects of chronic ethanol administration on poly-phosphoinositide metabolism in the mouse brain: Variance with age. Neurochem. Int., 22: 11–17.PubMedCrossRefGoogle Scholar
  42. Tabakoff B., Munoz-Marcus M. and Fields J.A., 1979, Chronic ethanol feeding produces an increase in muscarinic cholinergic receptors in mouse brain. Life Sci., 25: 2173–2180.PubMedCrossRefGoogle Scholar
  43. Takazawa K., Vandekerckhove J., Dumont J. and Erneux C., 1990, Cloning and expression in Escherichia coli of rat brain cDNAencodinga Ca2+ /calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase. Biochem J., 272: 107–112.PubMedGoogle Scholar
  44. Wood W.G., Armbrecht H.J. and Wise R.W., 1982, Ethanol intoxication and withdrawal among three age groups of C57BL/6NNIA mice. Pharmacol. Biochem. Behav., 17: 1037–1041.PubMedCrossRefGoogle Scholar
  45. Wood W.G. and Schroeder F., 1988, MiniReview: Membrane effects of ethanol: Bulk lipid versus lipid domains. Life Sci., 43: 467–475.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Grace Y. Sun
    • 1
  • Jian-ping Zhang
    • 1
  • Tai-An Lin
    • 1
  1. 1.Biochemistry DepartmentUniversity of MissouriColumbiaUSA

Personalised recommendations