Advertisement

The Oxygen Permeability of Cultured Endothelial Cell Monolayers

  • C. Y. Liu
  • S. G. Eskin
  • J. D. Hellums
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 345)

Abstract

The first barrier encountered by oxygen after exiting the lumen of the capillary is the capillary wall endothelium. Prior workers’ estimates of the oxygen permeability of the endothelium have differed by orders of magnitude, with some studies suggesting that the endothelial resistance to oxygen transport is of dominant importance (Rasio and Goresky, 1979; Rose and Goresky, 1985; Fletcher and Schubert, 1984). The present study was undertaken to directly measure the oxygen permeability of cultured bovine aortic, and human umbilical vein endothelial cell monolayers

Keywords

Human Umbilical Vein Endothelial Cell Mass Transfer Coefficient Silicone Rubber Oxygen Transport Diffusion Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Altman, P. L., and Diller, D. S., 1971, “Biological Handbooks: Respiration and Circulation,” Federation of American Societies for Experimental Biology, Bethesda, MD.Google Scholar
  2. Baxley, P. T., and Hellums, J. D., 1983, A simple model for simulation of oxygen transport in the microcirculation, Annals of Bionted. Eng., 11:401.CrossRefGoogle Scholar
  3. Fletcher, J. E., and Schubert, R. W., 1984, Capillary wall permeability effects in perfused capillary/tissue structures, in:“Adv. Exp. Med. and Biol., Vol. 180,” D. Bruley, H.I. Bicher, and D. Reneau, eds., Plenum Press, New York and London.Google Scholar
  4. Galletti, P. M., Snider, M. T., and Silbert-Aidcn, D., 1966, Gas permeability of plastic membranes for artificial lungs, Med. Res. Eng. 2nd Quarter 1966:20.Google Scholar
  5. Groebe, K. and Thews, G., 1986, Theoretical analysis of oxygen supply to contracted skeletal muscle, in:“Adv. Exp. Med. and Biol., Vol 200,” I. S. Longmuir, ed., Plenum Press, New York and London.Google Scholar
  6. Hellums, J. D., 1977, The resistance to oxygen transport in the capillaries relative to that in the surrounding tissue, Microvas. Res. 13:131.CrossRefGoogle Scholar
  7. Liu, C. Y., 1992, “A Study on the Resistances to Oxygen Transport in the Microcirculation,” Ph.D. thesis, Rice University, Houston.Google Scholar
  8. Major, C. J., and Kammermeyer, K., 1962, Gas permeability of plastics, Modern Plastics 39(no.11):135.Google Scholar
  9. Rasio, E. A., and Goresky, C. A., 1979, Capillary limitation of oxygen distribution in the isolated rete mirabile of the eel (anguilla anguilla), Circ. Res. 44:498.PubMedCrossRefGoogle Scholar
  10. Rose, C. P., and Goresky, C. A., 1985, Limitation of oxygen uptake in the canine coronary circulation, Circ. Res. 56:57.PubMedCrossRefGoogle Scholar
  11. Vaupel, P., 1976, Effect of percentual water content in tissues and liquids on the diffusion coefficients of O2, CO2, N2, and HZ, Pflugeis Arch. 361:201.CrossRefGoogle Scholar
  12. Weibel, E. R., 1984, “The Pathway for Oxygen,” Harvard University Press, Cambridge MA, and London.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • C. Y. Liu
    • 1
  • S. G. Eskin
    • 2
  • J. D. Hellums
    • 1
  1. 1.Department of Chemical EngineeringRice UniversityHoustonUSA
  2. 2.Department of Internal MedicineUniversity of Texas Medical SchoolHoustonUSA

Personalised recommendations