The Relationship of Radiation Sensitivity and Microenvironment of Human Tumor Cells in Multicellular Spheroid Tissue Culture

  • A. Görlach
  • H. Acker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 345)


Despite many publications describing a correlation between radioresistance and radiobiological hypoxia (Adams, 1990; Hill and Pallavicini,1984; Rockwell and Moulder, 1990) the importance of this phenomenon is still under discussion as well as the mechanisms relevant for the outcome to radiotherapy (Deacon et al.,1984; Steel and Peacock,1989).


Human Tumor Cell Line Spinner Flask Squamous Cell Carcinoma Cell Line Multicellular Spheroid High Radiosensitivity 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • A. Görlach
    • 1
  • H. Acker
    • 1
  1. 1.Max-Planck-Institut für SystemphysiologieDortmund 1Germany

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