The Relationship of Radiation Sensitivity and Microenvironment of Human Tumor Cells in Multicellular Spheroid Tissue Culture
Despite many publications describing a correlation between radioresistance and radiobiological hypoxia (Adams, 1990; Hill and Pallavicini,1984; Rockwell and Moulder, 1990) the importance of this phenomenon is still under discussion as well as the mechanisms relevant for the outcome to radiotherapy (Deacon et al.,1984; Steel and Peacock,1989).
KeywordsHuman Tumor Cell Line Spinner Flask Squamous Cell Carcinoma Cell Line Multicellular Spheroid High Radiosensitivity
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