Angiotensin Receptors and Renal Function

  • David P. Chan
  • John C. BurnettJr.


Angiotensin II (ANG II) is an important and potent regulator of renal function. With the discovery of specific types of angiotensin receptors and the availability of specific receptor antagonists, a body of information is evolving to describe the specific function of these important receptors. Along with insights in the physiological actions of ANG II on these receptors, variability in the type and localization of ANG II receptors within the renal system has been described. In addition, a maturational difference in the type of receptors exists in the development of the kidney.


Adrenal Gland Proximal Tubule Mesangial Cell Fractional Excretion Renal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Blantz RC: The glomerular and tubular actions of angiotensin II. Am J Kidney Dis 10(1 Suppl l):2–6, 1987.PubMedGoogle Scholar
  2. 2.
    Dworkin LD, Brenner BM: Hormonal modulation of glomerular function. Am J Physiol 244:F95–F104, 1983.PubMedGoogle Scholar
  3. 3.
    Douglas JG: Angiotensin receptor subtypes of the kidney cortex. Am J Physiol 253:F1–F7, 1987.PubMedGoogle Scholar
  4. 4.
    Hall JE: Control of sodium excretion by angiotensin II: Intrarenal mechanisms and blood pressure regulation. Am J Physiol 250:R960–R972, 1986.PubMedGoogle Scholar
  5. 5.
    Levens NR, Peach MJ, Carey RM: Role of the intrarenal renin—angiotensin system in the control of renal function. Circulation 48(2): 157–167, 1981.CrossRefGoogle Scholar
  6. 6.
    Herblin WF, Chiu AT, McCall DE, et al: Angiotensin II receptor heterogeneity. Am J Hypertens 4:299S–302S, 1991.PubMedGoogle Scholar
  7. 7.
    Chiu AT, Herblin WF, McCall DE, et al: Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 165(1): 196–203, 1989.PubMedCrossRefGoogle Scholar
  8. 8.
    Chiu AT, McCall DE, Price WA, et al: Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 252(2):711–718, 1990.PubMedGoogle Scholar
  9. 9.
    Rhaleb N-E, Rouissi N, Nantel F, et al: DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17:480–484, 1991.PubMedCrossRefGoogle Scholar
  10. 10.
    Wong PC, Price WAJ, Chiu AT, et al: In vivo pharmacology DuP 753. Am J Hypertens 4(4):288S–298S, 1991.PubMedGoogle Scholar
  11. 11.
    Wong PC, Price WA, Chiu AT, et al: Nonpeptide angiotensin II receptor antagonists. VII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 252(2):719–725, 1990.PubMedGoogle Scholar
  12. 12.
    Burns KD, Inagami T, Harris RC: Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol 264(4 Pt 2):F645–654, 1993.PubMedGoogle Scholar
  13. 13.
    Sechi LA, Griffin CA, Grady EF, et al: Characterization of angiotensin II receptor subtypes in rat heart. Circ Res 71(6): 1482–1489, 1992.PubMedCrossRefGoogle Scholar
  14. 14.
    Chang RS, Lotti VJ: Angiotensin receptor subtypes in rat, rabbit and monkey tissues: Relative distribution and species dependency. Life Sci 49(20): 1485–1490, 1991.PubMedCrossRefGoogle Scholar
  15. 15.
    Gibson RE, Thorpe HH, Cartwright ME, et al: Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys. Am J Physiol 261(3 Pt 2):F512–F518, 1991.PubMedGoogle Scholar
  16. 16.
    Grady EF, Sechi LA, Griffin CA, et al: Expression of AT2 receptors in the developing rat fetus. J Clin Invest 88(3):921–933, 1991.PubMedCrossRefGoogle Scholar
  17. 17.
    Gröne HJ, Simon M, Fuchs E: Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney. Am J Physiol 262(2 Pt 2): F326–F331, 1992.PubMedGoogle Scholar
  18. 18.
    Dudley DT, Panek RL, Major TC, et al: Subclasses of angiotensin II binding sites and their functional significance. Mol Pharmacol 38(3):370–377, 1990.PubMedGoogle Scholar
  19. 19.
    Iwai N, Inagami T: Regulation of the expression of the rat angiotensin II receptor mRNA. Biochem Biophys Res Commun 182(3): 1094–1099, 1992.PubMedCrossRefGoogle Scholar
  20. 20.
    Yamada H, Sexton PM, Chai SY, et al: Angiotensin II receptors in the kidney. Localization and physiological significance. Am J Hypertens 3(3):250–255, 1990.PubMedGoogle Scholar
  21. 21.
    Chansel D, Czekalski S, Pham P, et al: Characterization of angiotensin II receptor subtypes in human glomeruli and mesangial cells. Am J Physiol 262(3 Pt 2):F432–441, 1992.PubMedGoogle Scholar
  22. 22.
    Cogan MG, Xie MH, Liu FY, et al: Effects of DuP 753 on proximal nephron and renal transport. Am J Hypertens 4(4 Pt 2):315S–320S, 1991.PubMedGoogle Scholar
  23. 23.
    Cogan MG, Liu FY, Wong PC, et al: Comparison of inhibitory potency by nonpeptide angiotensin II receptor antagonists PD 123177 and DuP 753 on proximal nephron and renal transport. J Pharmacol Exp Ther 259(2):687–691, 1991.PubMedGoogle Scholar
  24. 24.
    Edwards RM, Stack EJ, Weidley EF, et al: Characterization of renal angiotensin II receptors using subtype selective antagonists. J Pharmacol Exp Ther 260(N):933–938, 1992.PubMedGoogle Scholar
  25. 25.
    Sechi LA, Grady EF, Griffin CA, et al: Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol 262(2 pt 2):F236–240, 1992.PubMedGoogle Scholar
  26. 26.
    Chan DP, Sandok EK, Aarhus LL, et al: Renal specific actions of angiotensin II receptor antagonism in the anesthetized dog. Am J Hypertens 5:354–360, 1992.PubMedGoogle Scholar
  27. 27.
    Clark KL, Robertson MJ, Drew GM: Role of angiotensin AT1 and AT2 receptors in mediating the renal effects of angiotensin II in the anaesthetized dog. Br J Pharmacol 109(1): 148–156, 1993.PubMedCrossRefGoogle Scholar
  28. 28.
    Edwards RM, Aiyar N: Angiotensin II receptor subtypes in the kidney. J Am Soc Nephrol 3:1643–1652, 1993.PubMedGoogle Scholar
  29. 29.
    Schnermann J, Briggs JP: Effect of angiotensin and other pressor agents on tubuloglomerular feedback responses. Kidney Int Suppl 30:S77–80, 1990.PubMedGoogle Scholar
  30. 30.
    Keiser JA, Bjork FA, Hodges JC, et al: Renal hemodynamic and excretory responses to PD 123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands. J Pharmacol Exp Ther 262(3): 1154–1160, 1992.PubMedGoogle Scholar
  31. 31.
    Myers BD, Deen WM, Brenner BM: Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Circ Res 37:101–110, 1975.PubMedCrossRefGoogle Scholar
  32. 32.
    Nobes MS, Harris PJ, Yamada H, et al: Effects of angiotensin on renal cortical and papillary blood flows measured by laser-Doppler flowmetry. Am J Physiol 261(6 Pt 2):F998–1006 1991.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • David P. Chan
    • 1
  • John C. BurnettJr.
    • 2
  1. 1.Division of Cardiology, Children’s HospitalOhio State UniversityColumbusUSA
  2. 2.Department of Cardiovascular DiseasesMayo ClinicRochesterMinnesotaUSA

Personalised recommendations