Advertisement

Angiotensin II Receptor Subtypes and Growth

  • Mohan Viswanathan
  • Juan M. Saavedra

Abstract

It is becoming increasingly clear that the renin-angiotensin system has a profound influence on growth besides the well-known physiological action on blood pressure regulation and control of fluid volume.1–4 Angiotensin II (ANG II) induces the expression of growth-related proto-oncogenes c-fos 5–7 and c-myc 8 Expression of growth factors like platelet-derived growth factor (PDGF)8,9 and extracellular matrix components like thrombospondin10 and tenascin11,12 is also induced by ANG II. Recently, hepatocyte nuclei have been demonstrated to express binding sites for ANG II,13,14 indicating that the peptide may also act through nuclear receptors. ANG II therefore may exert a direct action on growth or in some cases mediate its effect by interacting with growth factors.

Keywords

Vascular Smooth Muscle Cell Receptor Subtype Consecutive Section R3T3 Cell Superficial Dermis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schelling P, Fischer H, Ganten D: Angiotensin and cell growth: A link to cardiovascular hypertrophy? J Hypertens 9:3–15, 1991.PubMedGoogle Scholar
  2. 2.
    Re R: Angiotensin and the regulation of cellular growth. Am J Hypertens 4:217S–219S, 1991.PubMedGoogle Scholar
  3. 3.
    Katz AM: Angiotensin II: Hemodynamic regulator or growth factor? J Mol Cell Cardiol 22:739–747, 1990.PubMedCrossRefGoogle Scholar
  4. 4.
    Heagerty AM: Angiotensin II: Vasoconstrictor or growth factor? J Cardiovasc Pharmacol 18:S14–S19, 1991.PubMedGoogle Scholar
  5. 5.
    Kawahara Y, Sunako M, Tsuda T, et al: Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 150:52–59, 1988.PubMedCrossRefGoogle Scholar
  6. 6.
    Taubman MB, Berk BC, Izumo S, et al: Angiotensin II induces c-fos mRNA in aortic smooth muscle: Role of Ca2+ mobilization and protein kinase C activation. J Biol Chem 264:526–530, 1989.PubMedGoogle Scholar
  7. 7.
    Naftilan AJ, Pratt RE, Eldridge CS, et al: Angiotensin II induces c-fos expression in smooth muscle via transcriptional control. Hypertension 13:706–711, 1989.PubMedCrossRefGoogle Scholar
  8. 8.
    Naftilan AJ, Pratt RE, Dzau VJ: Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 83:1419–1424, 1989.PubMedCrossRefGoogle Scholar
  9. 9.
    Araki S, Kawahara Y, Kariya K, et al: Stimulation of platelet derived growth factor-induced DNA synthesis by angiotensin II in rabbit vascular smooth muscle cells. Biochem Biophys Res Commun 168:350–357, 1990.PubMedCrossRefGoogle Scholar
  10. 10.
    Scott-Burden T, Bühler FR: Regulation of smooth muscle proliferative phenotype by heparainoid-matrix interactions. Trends Pharmacol Sci 9:94–98, 1988.PubMedCrossRefGoogle Scholar
  11. 11.
    Sharifi BG, LaFleur DW, Pirola CJ, et al: Angiotensin II regulates tenascin gene expression in vascular smooth muscle cells. J Biol Chem 267:23910–23915, 1992.PubMedGoogle Scholar
  12. 12.
    Mackie EJ, Scott-Burden T, Hahn AW, et al: Expression of tenascin by vascular smooth muscle cells: Alterations in hypertensive rats and stimulation by angiotensin II. Am J Pathol 141:377–388, 1992.PubMedGoogle Scholar
  13. 13.
    Booz GW, Conrad KM, Hess AL, et al: Angiotensin II-binding sites on hepatic nuclei. Endocrinology 130:3641–3649, 1992.PubMedCrossRefGoogle Scholar
  14. 14.
    Tang SS, Rogg H, Schumacher R, et al: Characterization of nuclear angiotensin II-binding sites in rat liver and comparison with plasma membrane receptors. Endocrinology 131:374–380, 1992.PubMedCrossRefGoogle Scholar
  15. 15.
    Millan MA, Caravallo P, Izumi S-I, et al: Novel sites of expression of functional angiotensin II receptors in the late gestation fetus. Science 244:1340–1342, 1989.PubMedCrossRefGoogle Scholar
  16. 16.
    Bumpus FM, Catt KJ, Chiu AT, et al: Nomenclature for angiotensin receptors: A report of the nomenclature committee of the council for high blood pressure research. Hypertension 17:720–721, 1991.PubMedCrossRefGoogle Scholar
  17. 17.
    Tsutsumi K, Strömberg C, Viswanathan M, et al: Angiotensin II receptor subtypes in fetal tissues of the rat: Autoradiography, guanine nucleotide sensitivity, and association with phosphoinositide hydrolysis. Endocrinology 129:1075–1082, 1991.PubMedCrossRefGoogle Scholar
  18. 18.
    Grady EF, Sechi LA, Griffin CA, et al: Expression of AT2 receptors in the developing rat fetus J Clin Invest 88:921–933, 1991.PubMedCrossRefGoogle Scholar
  19. 19.
    Viswanathan M, Tsutsumi K, Correa FMA, et al: Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem Biophys Res Commun 179:1361–1367, 1991.PubMedCrossRefGoogle Scholar
  20. 20.
    Chang RS, Lotti VJ: Angiotensin receptor subtypes in rat, rabbit and monkey tissues. Relative distribution and species dependency. Life Sci 49:1485–1490, 1991.PubMedCrossRefGoogle Scholar
  21. 21.
    Keiser JA, Major TC, Lu GH, et al: Is there a functional cardiovascular role for AT2 receptors? Drug Dev Res 29:94–99, 1993.CrossRefGoogle Scholar
  22. 22.
    Gröne H-J, Simon M, Fuchs E: Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney. Am J Physiol 262:F326–F331, 1992.PubMedGoogle Scholar
  23. 23.
    Sechi LA, Grady EF, Griffin CA, et al: Characterization of angiotensin II receptor subtypes in the rat kidney and heart using the non-peptide antagonists DuP 753 and PD 123177. J Hypertens 9:S224–S225, 1991.Google Scholar
  24. 24.
    Sechi LA, Grady EF, Griffin CA, et al: Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol 262:F236–F240, 1992.PubMedGoogle Scholar
  25. 25.
    Ciuffo GM, Viswanathan M, Seltzer AM, et al: Glomerular angiotensin II receptor subtypes during development of rat kidney. Am J Physiol 265:F254–F271, 1993.Google Scholar
  26. 26.
    Rogg H, Schmid A, de Gasparo, M: Identification and characterization of angiotensin II receptor subtypes in rabbit ventricular myocardium. Biochem Biophys Res Commun 173:416–422, 1990.PubMedCrossRefGoogle Scholar
  27. 27.
    Sechi LA, Griffin CA, Grady EF, et al: Characterization of angiotensin II receptor subtypes in rat heart. Circ Res 71:1482–1489, 1992.PubMedCrossRefGoogle Scholar
  28. 28.
    Dostal DE, Baker KM: Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart: Mediation by the AT1 receptor. Am J Hypertens 5:276–280, 1992.PubMedGoogle Scholar
  29. 29.
    Johnson MC, Aguilera G: Angiotensin II receptor subtypes and coupling to signaling systems in cultured fetal fibroblasts. Endocrinology 129:1266–1274, 1991.PubMedCrossRefGoogle Scholar
  30. 30.
    Dudley DT, Hubell SE, Summerfelt RM: Characterization of angiotensin II (AT2) binding sites in R3T3 cells. Mol Pharmacol 40:360–367, 1991.PubMedGoogle Scholar
  31. 31.
    Dudley DT, Summerfelt RM: Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells. Regul Pept 44:199–206, 1993.PubMedCrossRefGoogle Scholar
  32. 32.
    Tsutsumi K, Viswanathan M, Strömberg C, et al: Type-1 and type-2 angiotensin II receptors in fetal rat brain. Eur J Pharmacol 198:89–92, 1991.PubMedCrossRefGoogle Scholar
  33. 33.
    Tsutsumi K, Saavedra JM: Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. Am J Physiol 261, R209–R215, 1991.PubMedGoogle Scholar
  34. 34.
    Viswanathan M, Saavedra JM: Expression of angiotensin II AT2 receptors in the rat skin during experimental wound healing. Peptides 13:783–786, 1992.PubMedCrossRefGoogle Scholar
  35. 35.
    Kimura B, Sumners C, Phillips MI: Changes in skin angiotensin II receptors in rats during wound healing. Biochem Biophys Res Commun 187:1083–1090, 1992.PubMedCrossRefGoogle Scholar
  36. 36.
    Ross R: The pathogenesis of atherosclerosis: An update. N Engl J Med 314:488–500, 1986.PubMedCrossRefGoogle Scholar
  37. 37.
    Schwartz SM, Campbell GR, Campbell JH: Replication of smooth muscle cells in vascular disease. Circ Res 58:427–444, 1986.PubMedCrossRefGoogle Scholar
  38. 38.
    Powell JS, Clozel JP, Müller RKM, et al: Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 245:186–188, 1989.PubMedCrossRefGoogle Scholar
  39. 39.
    Daemen MJAP, Lombardi DM, Bosman FT, et al: Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res 68:450–156, 1991.PubMedCrossRefGoogle Scholar
  40. 40.
    Majesky MW, Schwartz SM: Smooth muscle diversity in arterial wound repair. Toxicol Pathol 18:554–559, 1990.PubMedGoogle Scholar
  41. 41.
    Viswanathan M, Strömberg C, Seltzer A, et al: Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta. J Clin Invest 90:1707–1712, 1992.PubMedCrossRefGoogle Scholar
  42. 42.
    Viswanathan M, Saavedra JM: Expression of angiotensin II AT1 receptors during development of neointima in the carotid artery of rats. FASEB J 7:A331, 1993.Google Scholar
  43. 43.
    Chen L, Re RN, Prakash O, et al: Angiotensin-converting enzyme inhibition reduces neuroblastoma cell growth rate. Proc Soc Exp Biol Med 196:280–283, 1991.PubMedGoogle Scholar
  44. 44.
    Ariza A, Fernandez LA, Inagami T, et al: Renin in glioblastoma multiforme and its role in neovascularization. Am J Clin Pathol 90:437–441, 1988.PubMedGoogle Scholar
  45. 45.
    Guerra FK, Ciuffo GM, Elizalde PV, et al: Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas. Biochem Biophys Res Commun 193:93–99, 1993.PubMedCrossRefGoogle Scholar
  46. 46.
    Fernandez LA, Twickerl J, Mead A: Neovascularization produced by angiotensin II. J Lab Clin Pathol 105:141–145, 1985.Google Scholar
  47. 47.
    Le Noble FAC, Hekking JWM, Van Straaten HWM, et al: Angiotensin II stimulates an-giogenesis in the chorioallantoic membrane of the chick embryo. Eur J Pharmacol 195:305–306, 1991.PubMedCrossRefGoogle Scholar
  48. 48.
    Fernandez LA, Casride VJ, Twickler J, et al: Renin-angiotensin and development of collateral circulation after renal ischemia. Am J Physiol 243:H869–H875, 1982.PubMedGoogle Scholar
  49. 49.
    Le Noble FAC, Schreurs NHJS, Van Straaten HWM, et al: Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane. Am J Physiol 264:R460–R465, 1993.PubMedGoogle Scholar
  50. 50.
    Ciuffo GM, Heemskerk FMJ, Saavedra JM: Purification and characterization of angiotensin AT2 receptors from newborn rat kidney. Proc Natl Acad Sci USA 90:11009–11013, 1993.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mohan Viswanathan
    • 1
  • Juan M. Saavedra
    • 1
  1. 1.Section on Pharmacology, Laboratory of Clinical ScienceNational Institute of Mental Health, National Institutes of HealthBethesdaUSA

Personalised recommendations