Angiotensin II Receptor Subtypes and Growth

  • Mohan Viswanathan
  • Juan M. Saavedra


It is becoming increasingly clear that the renin-angiotensin system has a profound influence on growth besides the well-known physiological action on blood pressure regulation and control of fluid volume.1–4 Angiotensin II (ANG II) induces the expression of growth-related proto-oncogenes c-fos 5–7 and c-myc 8 Expression of growth factors like platelet-derived growth factor (PDGF)8,9 and extracellular matrix components like thrombospondin10 and tenascin11,12 is also induced by ANG II. Recently, hepatocyte nuclei have been demonstrated to express binding sites for ANG II,13,14 indicating that the peptide may also act through nuclear receptors. ANG II therefore may exert a direct action on growth or in some cases mediate its effect by interacting with growth factors.


Vascular Smooth Muscle Cell Receptor Subtype Consecutive Section R3T3 Cell Superficial Dermis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mohan Viswanathan
    • 1
  • Juan M. Saavedra
    • 1
  1. 1.Section on Pharmacology, Laboratory of Clinical ScienceNational Institute of Mental Health, National Institutes of HealthBethesdaUSA

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