Clinical Experiences with 111In Labeled Human Polyclonal IgG

  • F. H. M. Corstens
  • W. J. G. Oyen
  • J. W. M. van der Meer
  • R. A. M. J. Claessens
Part of the NATO ASI Series book series (NSSA, volume 262)

Abstract

All currently available scintigraphic techniques to localize infection have serious limitations. 99mTechnetium(Tc) methylenediphosphonate lacks specificity. Physiological excretion of 67 gallium(Ga) in the gut hampers image interpretation of suspected abdominal infection. 67 Ga also accumulates in areas of bone remodelling and the physical characteristics of the radionuclide are not particularly good. Preparation of 111indium labelled autologous leucocytes (111In-WBC) is time consuming, complicated, costly and - in this HIV era - potentially dangerous for patients and staff. Moreover, in patients with decreased peripheral leucocyte counts the latter technique is practically impossible.

Keywords

Arthritis Hepatitis Leukemia Tuberculosis Anemia 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • F. H. M. Corstens
    • 1
  • W. J. G. Oyen
    • 1
  • J. W. M. van der Meer
    • 2
  • R. A. M. J. Claessens
    • 1
  1. 1.Department of Nuclear MedicineUniversity Hospital NijmegenNijmegenThe Netherlands
  2. 2.Department of General Internal MedicineUniversity Hospital NijmegenNijmegenThe Netherlands

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