Clinical Experiences with 111In Labeled Human Polyclonal IgG
All currently available scintigraphic techniques to localize infection have serious limitations. 99mTechnetium(Tc) methylenediphosphonate lacks specificity. Physiological excretion of 67 gallium(Ga) in the gut hampers image interpretation of suspected abdominal infection. 67 Ga also accumulates in areas of bone remodelling and the physical characteristics of the radionuclide are not particularly good. Preparation of 111indium labelled autologous leucocytes (111In-WBC) is time consuming, complicated, costly and - in this HIV era - potentially dangerous for patients and staff. Moreover, in patients with decreased peripheral leucocyte counts the latter technique is practically impossible.
KeywordsSingle Photon Emission Compute Tomography Prosthetic Joint Infection Infectious Focus Granulocytopenic Patient Medium Energy Collimator
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