Abstract
During one of our very first applications of 111Indium-oxine platelet labeling in patients with manifested atherosclerosis more than a decade ago now8, we discovered an extremely low labeling efficiency of only 16 % in contrast to the normal range of 80-95 %4. Beside discussing the problems of a technical mistake2,4,10, we were looking for underlying phenomena in potential candidates being the risk factors for the development of atherosclerosis, i.e. hyperlipoproteinemia (3; HLP), smoking and eventually an interference of drugs. In fact, this particular 56 years old male patient was suffering from isolated hypercholesterolemia (type Ha) according to Fredrickson with a total cholesterol of 424 mg/dl and a LDL-cholesterol of 398 mg/dl. As LDL is known to activate platelet function1,5, and to alter the cellular membrane phospholipid composition, an influence onto the labeling behaviour was quite likely.
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© 1994 Springer Science+Business Media New York
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Granegger, S., Neumann, I., Sinzinger, H. (1994). Platelet Labeling Parameters are Influenced by Lipids and Lipoproteins*. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_13
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DOI: https://doi.org/10.1007/978-1-4615-2462-5_13
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