Immune Responses to HPV 16 E7
There is a strong association between the presence of HPV DNA and the transformation of cervical. tissue to malignancy. This link provides a rare opportunity to target a tumour immunologically through specific proteins of the causal. agent. Proteins involved in transformation are linked to the malignant phenotype and are therefore likely to be maintained in tumours.
Unable to display preview. Download preview PDF.
- 1.Tommasino, M., Contorni, M., Scarlato, V., Bugnoli, M., Maundrell, K., and Cavalieri, F., Synthesis, phosphorylation, and nuclear localisation of human papillomavirus E7 protein in Schizosaccharomyes pombe, Gene, 93:265 (1990)Google Scholar
- 3.Van Nest, G., K.S. Steimer, N.L. Haigwood, R.L. Burke and G. Ott., Advanced adjuvant formulations for use with recombinant subunit vaccines. In: Vaccines 92. Modem Approaches to New Vaccines. Eds. R.M. Chanock, R.A. Lerner, F. Brown and H. Ginsburg. Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y., pp. 57–62 (1992).Google Scholar