Immune Responses to HPV 16 E7

  • Merilyn H. Hibma
  • M. Tommasino
  • G. Van Nest
  • S. J. Ely
  • M. Contorni
  • R. Rappuoli
  • L. V. Crawford

Abstract

There is a strong association between the presence of HPV DNA and the transformation of cervical. tissue to malignancy. This link provides a rare opportunity to target a tumour immunologically through specific proteins of the causal. agent. Proteins involved in transformation are linked to the malignant phenotype and are therefore likely to be maintained in tumours.

Keywords

Primary Immunisation Serum Antibody Response Secondary Immunisation Subsequent Tumour Challenge Express Target Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Merilyn H. Hibma
    • 1
  • M. Tommasino
    • 1
  • G. Van Nest
    • 2
  • S. J. Ely
    • 1
  • M. Contorni
    • 3
  • R. Rappuoli
    • 3
  • L. V. Crawford
    • 1
  1. 1.ICRF Tumour Virus Group, Department of PathologyUniversity of CambridgeCambridgeUK
  2. 2.Chiron CorporationEmeryvilleUSA
  3. 3.IRISSienaItaly

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