Detection of Human Papillomavirus, Epstein Barr Virus and Elevated or Mutant P53 Expression in Squamous Cell Carcinoma of the Head and Neck

  • Ilona Lewensohn-Fuchs
  • Eva Munck-Wikland
  • Zsofia Berke
  • Gorm Pallesen
  • Annika Linde
  • Klas G. Wiman
  • Tina Dalianis

Abstract

Human malignancies arising from the head and neck region represent a significant cause of morbidity and mortality world-wide. Tobacco and alcohol are regarded to be the most important risk factors, whereas diet and smokeless tobacco are considered to be of major importance in high endemic areas (for review see Vokes et al., 1993). Increasing evidence suggests that viruses, e.g. Epstein Barr virus (EBV) and human papillomavirus (HPV), as well as mutation of tumour suppressor genes possibly caused by exogenous carcinogens, can contribute to the development of head and neck cancer (for review see Vokes et al., 1993).

Keywords

Adenoma Paraffin dNTP Papilloma 

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Ilona Lewensohn-Fuchs
    • 1
  • Eva Munck-Wikland
    • 2
  • Zsofia Berke
    • 1
    • 3
    • 4
  • Gorm Pallesen
    • 5
  • Annika Linde
    • 6
  • Klas G. Wiman
    • 4
  • Tina Dalianis
    • 1
    • 3
    • 4
  1. 1.Dept. of Clinical Virology, F69Huddinge HospitalHuddingeSweden
  2. 2.Dept. of OtorhinolaryngologyKarolinska HospitalStockholmSweden
  3. 3.Dept. of Clinical Immunology, F79Huddinge HospitalHuddingeSweden
  4. 4.Dept. of Tumour BiologyKarolinska InstituteStockholmSweden
  5. 5.Laboratory of ImmunopathologyUniversity Institute of Pathology, Aarhus KommunehospitalAarhus CDenmark
  6. 6.Dept. of VirologyNational Bacteriological Laboratory and Karolinska InstituteStockholmSweden

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