Diet and Estrogen Metabolism
The hypothesis that dietary constituents affect estrogen metabolism arose, in part, from epidemiological data suggesting that dietary fat was related to breast cancer1-3. These data showed that in populations that ate large quantities of animal fat the incidence of breast cancer was greater than in populations eating minimal amounts of animal fat1,2,4. Since there was evidence that estrogens might be associated with breast cancer, it was felt that low fat diets might reduce the risk of breast cancer by lowering estrogen levels.
KeywordsEthinyl Estradiol Metabolic Clearance Rate Estrogen Metabolism Estrone Sulfate Lower Estrogen Level
Unable to display preview. Download preview PDF.
- 15.Longcope C, Williams KIH. 1977. Ethynylestradiol and mestranol: their pharmacodynamics andeffects on natural estrogens. In: SGarattini — #HWBerendes (eds) Pharmacology of Steroid Contraceptive Drugs. Raven Press, New York, p 89.Google Scholar