Towards an Immunotherapy for p185HER2 Overexpressing Tumors

  • Paul Carter
  • Maria L. Rodrigues
  • Gail D. Lewis
  • Irene Figari
  • M. Refaat Shalaby
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 353)

Abstract

The protooncogene, HER2 (also known as c-erbB-2, neu, and HER-2 / neu) encodes a receptor tyrosine kinase, p185HER2 which is homologous to the EGF receptor (EGFr). HER2 was found to be amplified from 2 to 20-fold in up to ~ 30% of primary human breast cancers1. Furthermore, HER2 amplification was shown to be a strong prognosticator of decreased overall survival and overall time to relapse1 HER2 amplification and/or overexpression has subsequently been correlated with poor clinical prognosis in several additional malignant human diseases including: ovarian cancer2,3, endometrial cancer4,5, gastric cancer6 and adenocarcinoma of the lung7.

Keywords

Agar Lymphoma Tyrosine Adenocarcinoma Recombination 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Paul Carter
    • 1
  • Maria L. Rodrigues
    • 1
  • Gail D. Lewis
    • 2
  • Irene Figari
    • 3
  • M. Refaat Shalaby
    • 4
  1. 1.Departments of Protein EngineeringGenentech IncSouth San FranciscoUSA
  2. 2.Departments of Cell BiologyGenentech IncSouth San FranciscoUSA
  3. 3.Departments of EndocrinologyGenentech IncSouth San FranciscoUSA
  4. 4.Departments of Medicinal and Analytical ChemistryGenentech IncSouth San FranciscoUSA

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