Proinflammatory Role of Leukocyte Adhesion Molecules
The adhesive interaction between circulating leukocytes and the vessel wall is a critical event in host defense against microbial invasion and in the repair of tissue damage. Altered leukocyte-endothelial interactions, however, may sometimes contribute to the pathogenesis of vascular and tissue injury in inflammatory and immune disorders. This chapter will briefly summarize our current understanding of the molecular basis of leukocyte adherence to endothelium in inflammatory and immune reactions and discuss anti-adhesion therapy as a novel approach to the treatment of a wide spectrum of clinical disorders.
KeywordsMigration Arthritis Hydrogen Peroxide Ischemia Carbohydrate
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