Proinflammatory Role of Leukocyte Adhesion Molecules

  • John M. Harlan
  • Robert K. Winn
  • Nicholas B. Vedder
Part of the NATO ASI Series book series (NSSA, volume 257)

Abstract

The adhesive interaction between circulating leukocytes and the vessel wall is a critical event in host defense against microbial invasion and in the repair of tissue damage. Altered leukocyte-endothelial interactions, however, may sometimes contribute to the pathogenesis of vascular and tissue injury in inflammatory and immune disorders. This chapter will briefly summarize our current understanding of the molecular basis of leukocyte adherence to endothelium in inflammatory and immune reactions and discuss anti-adhesion therapy as a novel approach to the treatment of a wide spectrum of clinical disorders.

Keywords

Migration Arthritis Hydrogen Peroxide Ischemia Carbohydrate 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • John M. Harlan
    • 1
  • Robert K. Winn
    • 2
    • 3
  • Nicholas B. Vedder
    • 2
  1. 1.Department of Medicine/HematologyUniversity of WashingtonSeattleUSA
  2. 2.Department of SurgeryUniversity of WashingtonSeattleUSA
  3. 3.Department of BiophysicsUniversity of WashingtonSeattleUSA

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