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Proinflammatory Role of Leukocyte Adhesion Molecules

  • Chapter
Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 257))

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Abstract

The adhesive interaction between circulating leukocytes and the vessel wall is a critical event in host defense against microbial invasion and in the repair of tissue damage. Altered leukocyte-endothelial interactions, however, may sometimes contribute to the pathogenesis of vascular and tissue injury in inflammatory and immune disorders. This chapter will briefly summarize our current understanding of the molecular basis of leukocyte adherence to endothelium in inflammatory and immune reactions and discuss anti-adhesion therapy as a novel approach to the treatment of a wide spectrum of clinical disorders.

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Author information

Authors and Affiliations

  1. Department of Medicine/Hematology, University of Washington, Seattle, WA, 98195, USA

    John M. Harlan

  2. Department of Surgery, University of Washington, Seattle, WA, 98195, USA

    Robert K. Winn & Nicholas B. Vedder

  3. Department of Biophysics, University of Washington, Seattle, WA, 98195, USA

    Robert K. Winn

Authors
  1. John M. Harlan
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  2. Robert K. Winn
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  3. Nicholas B. Vedder
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Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    John D. Catravas

  2. Washington University Medical School, St. Louis, Missouri, USA

    Allan D. Callow

  3. T Cell Sciences, Inc., Cambridge, Massachusetts, USA

    Una S. Ryan

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© 1993 Springer Science+Business Media New York

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Harlan, J.M., Winn, R.K., Vedder, N.B. (1993). Proinflammatory Role of Leukocyte Adhesion Molecules. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2437-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6035-3

  • Online ISBN: 978-1-4615-2437-3

  • eBook Packages: Springer Book Archive

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