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Nitric Oxide Mediated Vasodilation in Response to Inflammatory Stimuli

  • John B. Warren
Part of the NATO ASI Series book series (NSSA, volume 257)

Abstract

Nitric oxide, derived from many cell types, has been implicated in all three components of acute inflammation: vasodilation, edema formation, and leukocyte accumulation. Vasodilation, causing an initial increase in blood flow, seems intuitively a logical response to tissue injury. However, the precise importance of vasodilation to the subsequent events is not known, although it is established that vasodilation potentiates both edema formation and leukocyte accumulation in several examples of the inflammatory response.

Keywords

Nitric Oxide Guanylate Cyclase Edema Formation Logical Response Inducible Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Warren, J.B., Coupjilan, M.L., Williams, TJ., 1992 (in press). Endotoxin-induced hyperemia in rat skin involves nitric oxide and prostaglandin synthesis. Br. J. Pharrnacol. Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • John B. Warren
    • 1
  1. 1.Department of Applied PharmacologyNational Heart & Lung InstituteLondonUK

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