Nitric Oxide Mediated Vasodilation in Response to Inflammatory Stimuli

  • John B. Warren
Part of the NATO ASI Series book series (NSSA, volume 257)


Nitric oxide, derived from many cell types, has been implicated in all three components of acute inflammation: vasodilation, edema formation, and leukocyte accumulation. Vasodilation, causing an initial increase in blood flow, seems intuitively a logical response to tissue injury. However, the precise importance of vasodilation to the subsequent events is not known, although it is established that vasodilation potentiates both edema formation and leukocyte accumulation in several examples of the inflammatory response.


Corticosteroid Arginine Prostaglandin Acetylcholine Indomethacin 


  1. Warren, J.B., Coupjilan, M.L., Williams, TJ., 1992 (in press). Endotoxin-induced hyperemia in rat skin involves nitric oxide and prostaglandin synthesis. Br. J. Pharrnacol. Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • John B. Warren
    • 1
  1. 1.Department of Applied PharmacologyNational Heart & Lung InstituteLondonUK

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