Abstract
Plasma levels of ET-1 (and its precursor big ET-1) are elevated in patients with acute myocardial infarction (Miyauchi et al., 1989). Cardiac membranes obtained from isolated perfused hearts of rats subjected to 30 min of global ischemia then reperfusion showed an increased density of ER-1 reduces infarct size after coronary artery ligation and reperfusion in anesthetized rats (Watanabe et al., 1990). Here we demonstrate that the vasoconstrictor effects of ET-1 in the coronary vascular bed are enhanced after 30 min of global myocardial ischemia followed by reperfusion. In addition, this study investigates whether a reduced formation of either prostacyclin or nitric oxide accounts for the ischemia-induced enhancement of the vasoconstnctor response to ET-1.
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References
Liu, J. et al., 1990, J. Cardiovasc. Phannacol. 15:436–443.
Miyauchi, T. et al., 1989, Lancet 2:53–54.
Watanabe, T. et al., 1990, Nature 348:673.
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© 1993 Springer Science+Business Media New York
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McMurdo, L., Thiemermann, C., Vane, J.R. (1993). Ischaemia and Reperfusion Enhances the Vasoconstrictor Effects of Endothelin-1 in the Isolated Perfused Heart of the Rat. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_38
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DOI: https://doi.org/10.1007/978-1-4615-2437-3_38
Publisher Name: Springer, Boston, MA
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