Abstract
Vascular endothelial cells synthesize nitric oxide (NO) from the terminal guanidine-nitrogen atom of the cationic amino acid L-arginine (Palmer, R et al, 1988). Although basal NO synthesis is not limited by arginine availability, under conditions of stimulated NO production or following substrate deprivation exogenous L-arginine appears to be rate-limiting (Palmer, R. et al., 1988). We have now investigated whether bradykinin, an agonist which is known to release NO release, modulates the endothelial cell L-arginine transporter.
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© 1993 Springer Science+Business Media New York
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Bogle, R.G., Coade, S.B., Moncada, S., Pearson, J.D., Mann, G.E. (1993). Bradykinin Stimulates L-Arginine Transport and Nitric Oxide Release in Vascular Endothelial Cells. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_16
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DOI: https://doi.org/10.1007/978-1-4615-2437-3_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6035-3
Online ISBN: 978-1-4615-2437-3
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