Natural Autoantibodies

  • Sylvia K. Chai
  • Liliana Mantovani
  • Marion T. Kasaian
  • Paolo Casali
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 347)


It has been recognized for at least half a century that normal individuals display circulating immunoglobulins (Ig) able to bind a variety of foreign antigens, such as bacteria, virus, fungi, as well as self antigens, such as nucleic acids, phospholipids, erythrocytes, serum proteins, cellular components, insulin, and thyroglobulin1–9. Because these antibodies arise independently of known and/or deliberate immunization, they have been termed natural antibodies. In contrast to antigen-induced antibodies, which are mainly IgG and monoreactive, a considerable proportion of natural antibodies are IgM and polyreactive, that is they bind several unrelated antigens with different affinities. Natural polyreactive and monoreactive IgG and IgA also exist7. Natural antibodies are produced mainly by CD5+ B cells, the predominant lymphocytes in the neonatal B cell repertoire10,11. Because of their broad reactivity for a wide variety of microbial components, natural antibodies play a major role in the primary line of defense against infections. Because of their ability to bind self antigens, they may provide the “templates” for the autoantibodies characteristic of autoimmune conditions, particularly those associated with expansion of CD5+ B cells, e.g., rheumatoid arthritis12-14.


Systemic Lupus Erythematosus Chronic Lymphocytic Leukemia Cell Repertoire Natural Antibody Soluble Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Sylvia K. Chai
    • 1
  • Liliana Mantovani
    • 1
  • Marion T. Kasaian
    • 1
    • 2
  • Paolo Casali
    • 1
  1. 1.The Department of Pathology and Kaplan Comprehensive Cancer CenterNew York University School of MedicineNew YorkUSA
  2. 2.Immulogic Pharmaceutical CorporationCambridgeUSA

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