Abstract
What is allergy? Usually the statement “I am allergic” suggests that one responds to the contact with a seemingly harmless extraneous entity in an adverse and exaggerated fashion. The term was originally coined by Pirquet in 1906, meaning “altered reactivity”, it was used to characterise the change in reaction which has occurred following exposure to an antigen. Present day immunologists attribute the manifestations of allergy to a condition where the immune system replies to the initial encounter with a foreign substance by producing an antibody of the immunoglobulin (Ig)E isotype, and the role of IgE antibodies in mediating the clinical symptoms of both immediate and delayed hypersensitivity reactions has been extensively documented since their discovery as a separate Ig class in 1966 1.
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Helm, B.A. (1994). Is there a Link Between the Nature of Agents that Trigger Mast Cells and the Induction of Immunoglobulin (IG)E Synthesis?. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VII. Advances in Experimental Medicine and Biology, vol 347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2427-4_1
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