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Immunologic Consequences of Transfusion

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Cardiac Surgery

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Abstract

The effect of blood transfusion on immune function in normal man is unknown-transfusions have never been given to normal volunteers followed by measurement of immune function. One must study patients who receive transfusions, measure the changes observed in immune cells and their function within the context of whatever disease they are being transfused for, and extrapolate this information to the effect of transfusing blood in the absence of disease. In observing similar changes in immune cells following transfusion for a variety of diseases, one can assume that these changes usually follow transfusion. Neither patients nor volunteers will ever be randomized to be transfused or untransfused. Patients scheduled for elective surgery can be randomized to participate in an autologous donation program or to receive blood prepared in some unique manner by filtering and/or washing. The changes in immune function following transfusion with their own blood or washed/filtered blood can be compared to patients who are receiving routinely prepared whole blood or packed cells. In this instance, the blood is given within the context of a surgical procedure as a consequence of operative blood loss which is due to trauma and trauma itself is associated with changes in immune cells and their function.

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Authors and Affiliations

  1. Mount Sinai Medical Center, New York, New York, USA

    Paul I. Tartter M.D.

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  1. Paul I. Tartter M.D.
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Editors and Affiliations

  1. Robert Wood Johnson Medical School at Camden, University of Medicine and Dentistry of New Jersey, Camden, New Jersey, USA

    Aurel C. Cernaianu M.D. (Associate Professor of Surgery, Director) & Anthony J. DelRossi M.D. (Professor of Surgery, Chairman, Head) (Associate Professor of Surgery, Director) &  (Professor of Surgery, Chairman, Head)

  2. Research Programs, Division of Cardiothoracic Surgery, Cooper Hospital/University Medical Center, Camden, New Jersey, USA

    Aurel C. Cernaianu M.D. (Associate Professor of Surgery, Director) (Associate Professor of Surgery, Director)

  3. Department of Surgery, Division of Cardiothoracic Surgery, Cooper Hospital/University Medical Center, Camden, New Jersey, USA

    Anthony J. DelRossi M.D. (Professor of Surgery, Chairman, Head) (Professor of Surgery, Chairman, Head)

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© 1994 Springer Science+Business Media New York

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Tartter, P.I. (1994). Immunologic Consequences of Transfusion. In: Cernaianu, A.C., DelRossi, A.J. (eds) Cardiac Surgery. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2423-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-2423-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6028-5

  • Online ISBN: 978-1-4615-2423-6

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