The Cell Cycle pp 359-366 | Cite as

Cells Undergoing HIV Envelope-Mediated Programmed Degeneration Accumulate in G2/M Phase

  • Huan Tian
  • Dan Hartmann
  • Larry Wahl
  • Eileen Donoghue
  • Clare McGowan
  • Jeffrey Cossman
  • Paul Russell
  • Lawrence Samelson
  • David I. Cohen
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Acquired immunodeficiency syndrome (AIDS) is a complex disease process induced by human immunodeficiency virus (HIV-1) infection.1 Although the linkage between HIV-1 infection and the development of AIDS has been established for a decade, 2 the molecular and biochemical basis for the profound and irreversible depletion of helper CD4+ T cells that follows HIV infection and paralyzes the immune system is not understood. A number of mechanisms have been proposed to account for CD4+ T killing by HIV, including the direct lysis of virally-infected cells, and the functional disruption of uninfected cells through an interaction with viral proteins.1,3,4 A recent hypothesis has proposed that, in HIV-infected individuals, there reemerges a cell death program normally utilized by immature T cells during development in response to specific stimuli accounting for both the early qualitative and late quantitative CD4+ T cell defects associated with AIDS.5

Keywords

Phenol EDTA Tyrosine Agarose Electrophoresis 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Huan Tian
    • 1
  • Dan Hartmann
    • 2
  • Larry Wahl
    • 3
  • Eileen Donoghue
    • 1
  • Clare McGowan
    • 4
  • Jeffrey Cossman
    • 2
  • Paul Russell
    • 4
  • Lawrence Samelson
    • 5
  • David I. Cohen
    • 1
  1. 1.Laboratory of ImmunoregulationNIAID, NIHBethesdaUSA
  2. 2.Department of PathologyGeorgetown University School of MedicineUSA
  3. 3.Laboratory of ImmunologyNIDH, NIHBethesdaUSA
  4. 4.Department of Molecular BiologyScripps Research InstituteLa JollaUSA
  5. 5.CBMBNICHD, NIHBethesdaUSA

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