The Cell Cycle pp 359-366 | Cite as

Cells Undergoing HIV Envelope-Mediated Programmed Degeneration Accumulate in G2/M Phase

  • Huan Tian
  • Dan Hartmann
  • Larry Wahl
  • Eileen Donoghue
  • Clare McGowan
  • Jeffrey Cossman
  • Paul Russell
  • Lawrence Samelson
  • David I. Cohen
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Acquired immunodeficiency syndrome (AIDS) is a complex disease process induced by human immunodeficiency virus (HIV-1) infection.1 Although the linkage between HIV-1 infection and the development of AIDS has been established for a decade, 2 the molecular and biochemical basis for the profound and irreversible depletion of helper CD4+ T cells that follows HIV infection and paralyzes the immune system is not understood. A number of mechanisms have been proposed to account for CD4+ T killing by HIV, including the direct lysis of virally-infected cells, and the functional disruption of uninfected cells through an interaction with viral proteins.1,3,4 A recent hypothesis has proposed that, in HIV-infected individuals, there reemerges a cell death program normally utilized by immature T cells during development in response to specific stimuli accounting for both the early qualitative and late quantitative CD4+ T cell defects associated with AIDS.5


Programme Cell Death Tyrosine Phosphorylation Jurkat Cell Okadaic Acid Cell Death Program 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Huan Tian
    • 1
  • Dan Hartmann
    • 2
  • Larry Wahl
    • 3
  • Eileen Donoghue
    • 1
  • Clare McGowan
    • 4
  • Jeffrey Cossman
    • 2
  • Paul Russell
    • 4
  • Lawrence Samelson
    • 5
  • David I. Cohen
    • 1
  1. 1.Laboratory of ImmunoregulationNIAID, NIHBethesdaUSA
  2. 2.Department of PathologyGeorgetown University School of MedicineUSA
  3. 3.Laboratory of ImmunologyNIDH, NIHBethesdaUSA
  4. 4.Department of Molecular BiologyScripps Research InstituteLa JollaUSA
  5. 5.CBMBNICHD, NIHBethesdaUSA

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