Heat Shock Genes and Cell Cycle Regulation During Early Mammalian Development
The formation of the mammalian forebrain is one of the least known processes in embryology and is extremely sensitive to heat shock.1 The structure of the early mammalian head and forebrain is predetermined in the neural plate during gastrulation. The development of the vertebrate nervous system begins with the induction of the neural plate on the dorsal surface of the embryo near the completion of gastrulation. Neural tube closure is one of the most critical stages of early embryogenesis. Heat shock interrupts neuroectoderm differentiation and can result in cell death and major developmental defects of the face and brain.A process closely linked to neural induction is the regionalization of the neural ectoderm along the anteriorposterior (AP) axis into prospective forebrain, midbrain hindbrain and spinal cord.
KeywordsHeat Shock Heat Shock Response Heat Shock Transcription Factor Neural Plate Heat Shock Gene
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