The Localisation of Human Cyclins and CDKS in the Cell Cycle
One of the emerging concepts in the cell cycle field is that progress through the cycle is determined at discrete points, called checkpoints, by a family of closely related protein kinases. This family has been christened the ‘cyclin-dependent kinases’ (CDKS), because they are only activated upon binding a member of the cyclin family. Cyclins appear to be required both to activate and to target their protein kinase partner to particular subcellular compartments. I have been attempting to define which part of the cyclin is responsible for its targetting function.
KeywordsFission Yeast Cdc25 Protein Mitotic Cyclins Related Protein Kinase Cell BioI
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