Control of G1 Progression by Mammalian D-Type Cyclins

  • Charles J. Sherr
  • Hitoshi Matsushime
  • Jun-ya Kato
  • Dawn E. Quelle
  • Martine F. Roussel
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Progression through the first gap phase (Gi) of the mammalian cell cycle is regulated by growth factors, but once cells commit to replicate their cellular DNA, they can undergo mitosis even if deprived of growth factors during ensuing cell cycle inter-vals.1 Recently isolated mammalian cyclins, including cyclins D1, D2, D3, and E, 2–6 appear likely to play central roles in integrating growth factor-induced signals with the cell cycle clock, thereby driving cells into S phase. To date, the hypothesis that D-type cyclins and cyclin E function to govern G1 transitions has rested largely on circumstantial evidence, but recent data now indicate that their activities are rate limiting for G1 progression and required for the entry of cells into the DNA synthetic (S) phase of the cell cycle.


Human Cyclin Retinoblastoma Gene Product LXCXE Motif Centrocytic Lymphoma Affect Cell Size 


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Charles J. Sherr
    • 1
    • 2
  • Hitoshi Matsushime
    • 2
  • Jun-ya Kato
    • 2
  • Dawn E. Quelle
    • 2
  • Martine F. Roussel
    • 2
  1. 1.Howard Hughes Medical InstituteSt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of Tumor Cell BiologySt. Jude Children’s Research HospitalMemphisUSA

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