Evaluation of a Physiological Tear Substitute in Patients with Keratoconjunctivitis Sicca

  • J. Daniel Nelson
  • Margaret M. Drake
  • James T. BrewerJr.
  • Michael Tuley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


In the absence of any definitive cure for dry eye disorders, artificial tears remain the only therapeutic choice. These lubricating products are marketed for relief of symptoms of dry eye. However, none are currently allowed for use on the basis of their amelioration of objective signs of dry eye.


Ocular Surface Rose Bengal Foreign Body Sensation Ocular Surface Disease Keratoconjunctivitis Sicca 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Versura, P., Maltarello, M.C., Stecher, F., Caramazza, R. and Laschi, R. (1989) Ophthalmologica 198, 152–162.PubMedCrossRefGoogle Scholar
  2. 2.
    Polack, F.M. and McNiece, M.T. (1982) Cornea 1, 133–136.Google Scholar
  3. 3.
    Stuart, J.C. and Linn, J.G. (1985) Ann Ophthalmol 17, 190–192.PubMedGoogle Scholar
  4. 4.
    DeLuise, V.P. and Peterson, W.S. (1984) Ann Ophthalmol 16, 823–824.PubMedGoogle Scholar
  5. 5.
    Sand, B.B., Marner, K. and Norn, M.S. (1989) Acta Ophthalmol (Copenh) 67, 181–183.CrossRefGoogle Scholar
  6. 6.
    Nelson, J.D. and Farris, R.L. (1988) Arch Ophthalmol 106, 484–487.PubMedCrossRefGoogle Scholar
  7. 7.
    Hawi, A.L., Smith, T.J. and Diogenis, G.A. (1990) Suppl to Invest Ophthalmol Vis Sci 31, 517.Google Scholar
  8. 8.
    Grene, R.B., Lankston, P., Mordaunt, J., Harrold, M., Gwon, A. and Jones, R. (1992) Cornea 11, 294–301.PubMedCrossRefGoogle Scholar
  9. 9.
    Gilbard, J.P., Rossi, S.R. and Heyda, K.G. (1989) 107, 348–355.Google Scholar
  10. 10.
    Gilbard, J.P. and Rossi, S.R. (1991) Suppl to Invest Ophthalmol Vis Sci 32, 1114.Google Scholar
  11. 11.
    Lopez Bernal, D. and Ubels, J.L. (1992) (In Press).Google Scholar
  12. 12.
    von Bijsterveld, O.P. (1969) Arch Ophthalmol 82, 10–14.PubMedCrossRefGoogle Scholar
  13. 13.
    Nelson, J.D. (1989) In: Contact Lenses: Update 5, Little, Brown and Co., p. 3C.1–3C.7.Google Scholar
  14. 14.
    Nelson, J.D., Gordon, J.F., and The Chiron KCS Study Group (1992) Am J Ophthalmol 114:441–447.PubMedGoogle Scholar
  15. 15.
    Gilbard, J.P. and Rossi, S.R. (1992) Ophthalmology 99, 600–604.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • J. Daniel Nelson
    • 1
    • 2
  • Margaret M. Drake
    • 3
  • James T. BrewerJr.
  • Michael Tuley
    • 3
  1. 1.Departments of Ophthalmology at Ramsey ClinicSt. Paul-Ramsey Medical CenterSt. PaulUSA
  2. 2.The University of MinnesotaMinneapolisUSA
  3. 3.Clinical SciencesAlcon Laboratories, Inc.Fort WorthUSA

Personalised recommendations