Skip to main content

Subclass Expression of IgA in Lacrimal Glands of Patients with Sjögren’s Syndrome

  • Chapter
Lacrimal Gland, Tear Film, and Dry Eye Syndromes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 350))

Abstract

Normally, the human lacrimal gland contains a high proportion of IgA secreting plasma cells. The secreted IgA has two subclasses, IgAl and IgA2, the expression of which may be controlled by T cells and/or cytokines. A high proportion (approximately 40%) of total lacrimal IgA occurs as IgA2, while IgA2 comprises about 10% of total serum IgA1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 379.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D.L. Delacroix, C. Dive, J.C. Rambaud, and J.P. Vaerman, IgA subclasses in various secretions and in serum. Immunology 47:383 (1982).

    PubMed  CAS  Google Scholar 

  2. R.I. Fox, C.A. Robinson, J.G. Curd, F. Kozin, and F. Howell, Sjögren’s syndrome, proposed criteria for classification. Arthritis Rheum. 29:577 (1975).

    Article  Google Scholar 

  3. S.S. Cargo and J. Mestecky, Secretory component: interactions with intracellular and surface immunoglobulins of human lymphoid cells, J. Immunol. 122:906 (1979).

    Google Scholar 

  4. P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidium thiocytephenol-chloroform extraction, Analyt. Diochem. 162:156 (1987).

    Article  CAS  Google Scholar 

  5. D.A. Rappolee, A.M. Wang, D. Mark, and Z. Weber, Noble method for studying mRNA phenotype in single or small numbers of cells, J. Cellul. Biochem. 39:1 (1989).

    Article  CAS  Google Scholar 

  6. H.E. Gendelman, R.M. Friedman, S. Joe, L.M. Baca, J.A. Turpin, G. Dveksler, M.S. Meltzer, and C. Dieffenbach, A selective defect of interferon α production in human immunodeficiency virus-infected monocytes, J. Exp. Med. 172:1433 (1990).

    Article  PubMed  CAS  Google Scholar 

  7. E.S. Kawasaki, S.S. Clark, M.Y. Coyne, S.D. Smith, R. Champlin, O.N. Witte, and F.P. McCormick, Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro, Proc. Acad. Sci. USA 85:5698 (1989).

    Article  Google Scholar 

  8. H.L. Chang, M.H. Zaroukian, and W.J. Esselman, T200 alternate exon use in murine lymphoid cells determined by reverse transcription-polymerase chain reaction, J. Immunol. 143:315 (1989).

    PubMed  CAS  Google Scholar 

  9. R.K. Saiki, T.L. Bugawan, G.T. Horn, K.B. Mullis, and H.A. Erich, Analysis of enzymatrically amplified β-globulin and HLA-DQα DNA with allele-specific oligonucleotide probes, Nature 324:163 (1986).

    Article  PubMed  CAS  Google Scholar 

  10. R.K. Saiki, D.H. Gelfand, S. Stoffel, S.J. Scharf, R. Higuchi, G.T. Horn, K.B. Mullis, and H.A. Erich HA, Primer-detected enzymatic amplification of DNA with a thermostable DNA polymerase, Science 239:487 (1988).

    Article  PubMed  CAS  Google Scholar 

  11. M.R. Allansmith, J. Radl, J.J. Haaijiman, and J. Mestecky, Molecular forms of tear IgA and distribution of IgA subelasses in human lacrimal glands, J. Allergy Clin. Immunol. 76:569 (1985).

    Article  PubMed  CAS  Google Scholar 

  12. S.S. Crago, W.H. Kulteh, I. Moro, M.R. Allansmith, J.J. Haaijiman, and J. Mestecky, Distribution of IgAl-, IgA2-, and J chain-containing cells in human tissues, J. Immunol. 132:16 (1984).

    PubMed  CAS  Google Scholar 

  13. J. Metstecky and M.W. Russei MW, IgA subclasses, in: “Basic and Clinical Aspects of IgG, Monographs in Allergy,” F. Shakib, ed., American Elsevier Publishing Co., New York (1986).

    Google Scholar 

  14. K. Fujihashi, J.R. McGhee, C. Lue, K.W. Beagley, T. Taga, T. Hirano, T. Kishimoto, J. Mestecky, and H. Kiyono, Human appendix B cells naturally express receptors for and respond to interleukin-6 with selective IgAl and IgA2 synthesis, J. Clin. Invest. 88:248 (1991).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ono, M., Yoshino, K., Tsubota, K., Saito, I. (1994). Subclass Expression of IgA in Lacrimal Glands of Patients with Sjögren’s Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_32

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2417-5_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6025-4

  • Online ISBN: 978-1-4615-2417-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics