Abstract
Normally, the human lacrimal gland contains a high proportion of IgA secreting plasma cells. The secreted IgA has two subclasses, IgAl and IgA2, the expression of which may be controlled by T cells and/or cytokines. A high proportion (approximately 40%) of total lacrimal IgA occurs as IgA2, while IgA2 comprises about 10% of total serum IgA1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.L. Delacroix, C. Dive, J.C. Rambaud, and J.P. Vaerman, IgA subclasses in various secretions and in serum. Immunology 47:383 (1982).
R.I. Fox, C.A. Robinson, J.G. Curd, F. Kozin, and F. Howell, Sjögren’s syndrome, proposed criteria for classification. Arthritis Rheum. 29:577 (1975).
S.S. Cargo and J. Mestecky, Secretory component: interactions with intracellular and surface immunoglobulins of human lymphoid cells, J. Immunol. 122:906 (1979).
P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidium thiocytephenol-chloroform extraction, Analyt. Diochem. 162:156 (1987).
D.A. Rappolee, A.M. Wang, D. Mark, and Z. Weber, Noble method for studying mRNA phenotype in single or small numbers of cells, J. Cellul. Biochem. 39:1 (1989).
H.E. Gendelman, R.M. Friedman, S. Joe, L.M. Baca, J.A. Turpin, G. Dveksler, M.S. Meltzer, and C. Dieffenbach, A selective defect of interferon α production in human immunodeficiency virus-infected monocytes, J. Exp. Med. 172:1433 (1990).
E.S. Kawasaki, S.S. Clark, M.Y. Coyne, S.D. Smith, R. Champlin, O.N. Witte, and F.P. McCormick, Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro, Proc. Acad. Sci. USA 85:5698 (1989).
H.L. Chang, M.H. Zaroukian, and W.J. Esselman, T200 alternate exon use in murine lymphoid cells determined by reverse transcription-polymerase chain reaction, J. Immunol. 143:315 (1989).
R.K. Saiki, T.L. Bugawan, G.T. Horn, K.B. Mullis, and H.A. Erich, Analysis of enzymatrically amplified β-globulin and HLA-DQα DNA with allele-specific oligonucleotide probes, Nature 324:163 (1986).
R.K. Saiki, D.H. Gelfand, S. Stoffel, S.J. Scharf, R. Higuchi, G.T. Horn, K.B. Mullis, and H.A. Erich HA, Primer-detected enzymatic amplification of DNA with a thermostable DNA polymerase, Science 239:487 (1988).
M.R. Allansmith, J. Radl, J.J. Haaijiman, and J. Mestecky, Molecular forms of tear IgA and distribution of IgA subelasses in human lacrimal glands, J. Allergy Clin. Immunol. 76:569 (1985).
S.S. Crago, W.H. Kulteh, I. Moro, M.R. Allansmith, J.J. Haaijiman, and J. Mestecky, Distribution of IgAl-, IgA2-, and J chain-containing cells in human tissues, J. Immunol. 132:16 (1984).
J. Metstecky and M.W. Russei MW, IgA subclasses, in: “Basic and Clinical Aspects of IgG, Monographs in Allergy,” F. Shakib, ed., American Elsevier Publishing Co., New York (1986).
K. Fujihashi, J.R. McGhee, C. Lue, K.W. Beagley, T. Taga, T. Hirano, T. Kishimoto, J. Mestecky, and H. Kiyono, Human appendix B cells naturally express receptors for and respond to interleukin-6 with selective IgAl and IgA2 synthesis, J. Clin. Invest. 88:248 (1991).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ono, M., Yoshino, K., Tsubota, K., Saito, I. (1994). Subclass Expression of IgA in Lacrimal Glands of Patients with Sjögren’s Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_32
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2417-5_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6025-4
Online ISBN: 978-1-4615-2417-5
eBook Packages: Springer Book Archive