The Lacrimal Antibody Response to Viral and Chlamydial Infections

  • Maureen G. Friedman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


Secretory IgA (sIgA) has been detected in tears of humans in response to both viral and chlamydial infections (reviewed by Friedman, 1990). These antibodies may be synthesized in the lacrimal gland as a result of stimulation of the common mucosal immune system, which leads to homing of sensitized lymphocytes to the various exocrine glands (Russell and Mestecky, 1988), or possibly as a result of local sensitization by as yet undetermined means. Antibodies of other isotypes specific for infectious agents (IgA lacking secretory component, IgG, IgM, and IgE) have also been detected in lacrimal fluid (McClellan et al., 1973). The purpose of this report is to survey some of the literature relevant to the lacrimal antibody response, to formulate some hypotheses, and to point out directions for future investigations.


Herpes Simplex Virus Chlamydia Trachomatis Lacrimal Gland Chlamydial Infection Secretory Component 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Maureen G. Friedman
    • 1
  1. 1.Virology Unit Faculty of Health SciencesBen Gurion University of the NegevBeer ShevaIsrael

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