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The Inositol Phosphate-Calcium Signalling System in Lacrimal Gland Cells

  • James W. PutneyJr.
  • Gary St. J. Bird
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)

Abstract

In lacrimal gland cells, receptor-activated Ca2+ mobilization involves two phases: 1) Ca2+ release from an intracellular store, and 2) a more prolonged phase of extracellular Ca2+ entry (Parod and Putney, 1978; Putney, 1987). These two phases of the Ca2+ response can be dissected by stimulating cells with a phospholipase C-linked agonist in the presence or absence of extracellular Ca2+. In the absence of extracellular Ca2+, such stimulation results in a transient increase in Ca2+, originating from the release of a finite intracellular Ca2+ pool. In the presence of physiological (mM) extracellular Ca2+, the elevation in [Ca2+]i is sustained due to the additional component of extracellular Ca2+ influx. Extracellular Ca2+ influx is also the source for refilling of the intracellular Ca2+ pool upon termination of receptor activation.

Keywords

Lacrimal Gland Inositol Phosphate Sinusoidal Oscillation Inositol Trisphosphate Negative Feed 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • James W. PutneyJr.
    • 1
  • Gary St. J. Bird
    • 1
  1. 1.Laboratory of Cellular and Molecular PharmacologyNational Institute of Environmental Health Sciences — NIHResearch Triangle ParkUSA

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