Sjögren’s Syndrome — Close to Cause and Cure?

  • Norman Talal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


Sjögren’s syndrome (SS) is a chronic autoimmune disease associated with the production of rheumatoid factor and other autoantibodies (1). Because it is characterized by lymphocytic and plasma cell infiltration and destruction of salivary and lacrimal glands, SS gives rise to the characteristic symptoms of dry mouth and dry eyes. The term “autoimmune exocrinopathy” has been applied to this disease. The lymphocytic infiltration can extend to other, more-vital organs, so SS is both a systemic (like SLE) and a localized (like autoimmune thyroiditis) autoimmune disorder.


Systemic Lupus Erythematosus Chronic Fatigue Syndrome Acquire Immune Deficiency Syndrome Lacrimal Gland Monoclonal Immunoglobulin 
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    N. Talal, H.M. Moutsopoulos, and S.S. Kassan, eds. “Sjögren’s Syndrome — Clinical and Immunological Aspects,” Springer-Verlag, Heidelberg (1987).Google Scholar
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    N. Talal, Sjögren’s syndrome and connective tissue disease with other immunologic disorders, in: “Arthritis and Allied Conditions” (ed 12), Koopman D & McCany D.ed., Lea & Febiger, Philadelphia, PA, pp. 1197–1207 (1989).Google Scholar
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    E. Flescher, and N. Talal, Do viruses contribute to the development of Sjögren’s syndrome?, Am. Jour. Med., 90:283285 (1991).Google Scholar
  4. 4.
    N. Talal, E. Flescher, and H. Dang, Are endogenous retroviruses involved in human autoimmune disease?, J. Autoimmun, 5:6166 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Norman Talal
    • 1
    • 2
  1. 1.Clinical Immunology SectionAudie L. Murphy Memorial Veterans HospitalSan AntonioUSA
  2. 2.Department of MedicineThe University of Texas Health Science Center at San AntonioSan AntonioUSA

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