Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren’s Syndrome

  • M. G. Humphreys-Beher
  • Y. Hu
  • Y. Nakagawa
  • P-L. Wang
  • K. R. Purushotham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


Sjögren’s syndrome (S.S.) in the human patient population is an autoimmune inflammatory disease presenting clinical symptoms of xerophthalmia and xerostomia1. This condition predominantly affects women. Most diagnoses of S.S. is made in association with autoimmune connective tissue diseases such as rheumatoid arthritis or systemic lupus erythematosus.2 However, it can also be obseved as an isolated phenomenon, described as primary S.S.


Salivary Gland Lacrimal Gland Saliva Flow Rate Salivary Gland Function Salivary Gland Dysfunction 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • M. G. Humphreys-Beher
    • 1
  • Y. Hu
    • 1
  • Y. Nakagawa
    • 1
  • P-L. Wang
    • 1
  • K. R. Purushotham
    • 1
  1. 1.Department of Oral BiologyUniversity of FloridaGainesvilleUSA

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