Ribosomal RNA Processing in

Van Nues, Rob W.; Venema, Jaap; Planta, Rudi J.; Raué, Hendrik A.

doi:10.1007/978-1-4615-2407-6_15

Ribosomal RNA Processing in Saccharomyces Cerevisiae

Rob W. Van Nues⁴,
Jaap Venema⁴,
Rudi J. Planta⁴ &
Hendrik A. Raué⁴

Chapter

272 Accesses
3 Citations

Abstract

Ribosome biogenesis in eukaryotic cells requires an intricate interplay between a large number of molecules. In the course of this process some 80 ribosomal proteins (r-proteins) have to assemble in an ordered fashion with the four rRNA molecules, which themselves are formed by stepwise maturation of primary transcripts produced by two different RNA polymerases. rRNA processing and r-protein assembly occur concomitantly and are interdependent. Furthermore, a growing number of non-ribosomal components, both proteins and ribonucleoprotein (RNP) particles, is being identified, that are required in trans for the correct and efficient formation of eukaryotic ribosomes. Because of its accessibility to genetic and physiological manipulation, the yeast Saccharomyces cerevisiae has become one of the most popular organisms for studying eukaryotic ribosome biogenesis. In this Chapter we will discuss recent progress in the identification of both cis-acting elements and trans-acting factors involved in the formation of the mature 17S, 26S and 5.8S rRNA species in yeast.

Keywords

rRNA Processing
rDNA Unit
External Transcribe Space
29SB Molecule
ITS1 ITS2

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

Department of Biochemistry and Molecular Biology, Vrije Universiteit, de Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands
Rob W. Van Nues, Jaap Venema, Rudi J. Planta & Hendrik A. Raué

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Rob W. Van Nues
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Jaap Venema
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Rudi J. Planta
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Hendrik A. Raué
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Max–Planck-Institut für Molekulare Genetik, Berlin, Germany
Knud H. Nierhaus, François Franceschi & Alap R. Subramanian, &
Freie Universität Berlin, Berlin, Germany
Volker A. Erdmann
Max–Delbrück-Centrum für Molekulare Medizin, Berlin, Germany
Brigitte Wittmann-Liebold

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Van Nues, R.W., Venema, J., Planta, R.J., Raué, H.A. (1993). Ribosomal RNA Processing in Saccharomyces Cerevisiae . In: Nierhaus, K.H., Franceschi, F., Subramanian, A.R., Erdmann, V.A., Wittmann-Liebold, B. (eds) The Translational Apparatus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2407-6_15

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DOI: https://doi.org/10.1007/978-1-4615-2407-6_15
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