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Ion Flux in Pulmonary Vascular Control pp 77–104Cite as

Fast Na+ Current and Ca2+ Currents in Smooth Muscles

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Part of the book series: NATO ASI Series ((NSSA,volume 251))

Abstract

Most smooth muscle (SM) cells normally do not possess fast Na+ channels, and inward current for the action potential (AP) is carried primarily through slow (L-type) Ca2+ channels. The slow Ca2+ channel activity is regulated by several mechanisms, as is well known for myocardial cells. In myocardial cells, cyclic AMP and cAMP-dependent protein kinase (cA-PK) stimulate slow Ca2+ channel activity, whereas cyclic GMP and cGMP-dependent protein kinase (cG-PK) inhibit channel activity (reviewed in Sperelakis et al., 1992). Phosphorylation by PK-C also stimulates activity of the myocardial slow Ca2+ channels (Domenici & Rogers, 1988). Intracellular ATP also modulates slow Ca2+ channel activity in myocardial cells, ATP being obligatory for channel activity (Sperelakis & Schneider, 1976; O’Rourke et al., 1992). Acidosis rapidly, reversibly, and rather selectively inhibits the slow Ca2+ channels in cardiac muscle (Vogel & Sperelakis, 1977; Belardinelli et al., 1979; Irisawa and Sato, 1987). Gating of myocardial Ca2+ slow channels by Gs-protein (GTP-activated alpha subunit) has also been demonstrated (Yatani et al., 1988). Intracellular ATP also modulates activity of slow Ca2+ channels in SM cells (Ohya and Sperelakis, 1989a, b), and phosphorylation by either cAMP or cGMP-mediated pathways inhibit slow Ca2+ channel activity (Bkaily et al., 1988a).

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Authors and Affiliations

  1. Department of Physiology & Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0576, USA

    Nicholas Sperelakis, Zhiling Xiong, Yoshihito Inoue, Yusuke Ohya, Keiichi Shimamura, David Bielefeld & John Lorenz

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  1. Nicholas Sperelakis
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  2. Zhiling Xiong
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  3. Yoshihito Inoue
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  4. Yusuke Ohya
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  5. Keiichi Shimamura
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  6. David Bielefeld
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Editors and Affiliations

  1. Veterans Administration Medical Center, Minneapolis, Minnesota, USA

    E. Kenneth Weir

  2. University of Nevada, Reno, Nevada, USA

    Joseph R. Hume

  3. University of Colorado, Denver, Colorado, USA

    John T. Reeves

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© 1993 Springer Science+Business Media New York

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Sperelakis, N. et al. (1993). Fast Na+ Current and Ca2+ Currents in Smooth Muscles. In: Weir, E.K., Hume, J.R., Reeves, J.T. (eds) Ion Flux in Pulmonary Vascular Control. NATO ASI Series, vol 251. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2397-0_7

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  • DOI: https://doi.org/10.1007/978-1-4615-2397-0_7

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