Redox Regulation of K+ Channels and Hypoxic Pulmonary Vasoconstriction
The pulmonary vasculature is unique in that hypoxia causes vasoconstriction; whereas, most systemic vessels dilate (Daut et al., 1990). Hypoxic pulmonary vasoconstriction (HPV) serves as an adaptive mechanism by which blood flow is diverted from poorly ventilated to better ventilated regions of the lung to optimize ventilation/perfusion matching (Archer and Weir, 1989a; Cutaia and Rounds, 1990).
KeywordsPulmonary Artery Carotid Body Rest Membrane Potential Hypoxic Pulmonary Vasoconstriction Voltage Ramp
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- Ammon, H.P.T., Akhtar, M.S., Niklas, H., and Hegner, D., 1977, Inhibition of p-chloromercuribenzoate-and glucose-induced insulin release in vitro by methylene blue, diamide, and tert-butyl hydroperoxide. Mol. Pharm. 13:598–605.Google Scholar
- Archer, S.L., McMurtry, I.F., and Weir, E.K., 1989a, Mechanisms of Acute Hypoxic and Hyperoxic Changes in Pulmonary Vascular Reactivity, in: “Pulmonary Vascular Physiology and Pathophysiology,” E.K. Weir and J.T. Reeves, eds., Marcel Dekker, Inc., New York p. 241–290.Google Scholar
- Archer, S.L., Peterson, D., Nelson, D.P., DeMaster, E.G., Kelly, B., Eaton, J.W., and Weir, E.K., 1989c, Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. J. Appl. Physiol. 6: 102–111.Google Scholar
- Archer, S.L., and Weir, E.K., 1989d, Mechanisms in Hypoxic Pulmonary Hypertension. In: “Pulmonary Circulation: Advances and Controversies. C.A. Wagenvoort and H. Denolin, eds., Elsevier Science Publishers, New York. p.87–113.Google Scholar
- Archer, S.L., Yankovich, R.D., Chesler, E., and Weir, E.K., 1985, Comparative effects of nisoldipine, nifedipine and bepridil on experimental pulmonary hypertension. J. Pharm. Exp. Ther. 233:12–17.Google Scholar
- Gelband, C.H., Ishikawa, T., Post, J.M., Keef, K.D. and Hume, J.R., 1993, Intracellular divalent cations block smooth muscle K+ channels. Circ. Res. in press.Google Scholar
- Mc Murtry, I.F., 1985, BAY K 8644 potentiates and A23187 inhibits hypoxic vasoconstriction in rat lungs. Am. J. Physiol. 249:H741–H746.Google Scholar
- Naeije, R., Lejeune, P., Vachiéry, J., Leeman, M., Mélot, Hallemans, R., Delcroix, M., and Brimioulle, S., 1990, Restored hypoxic pulmonary vasoconstriction by peripheral chemoreceptor agonists in dogs. Am. Rev. Respir. Dis. 142:789–795.Google Scholar
- Robertson, S.P., and Potter, J.D., 1984, “Methods In Pharmacology,” Plenum, New York p. 63–75.Google Scholar
- Salvaterra, C.G., and Goldman, W.F., 1991, Direct effects of hypoxia on apparent intracellular calcium levels in cultured pulmonary vascular smooth muscle cells. Am. Rev. Resp. Dis. 163:A373.Google Scholar
- Salvaterra, C.G., and Goldman, W.F., 1991, Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes. Am. J. Physiol. 264:L323–L328.Google Scholar
- Weir, E.K., and Will, J.A., 1982, Oxidants: a new group of pulmonary vasodilators. Clin Resp. Physiol. 18:81–85.Google Scholar