Redox Regulation of K+ Channels and Hypoxic Pulmonary Vasoconstriction

  • J. M. Post
  • E. K. Weir
  • S. L. Archer
  • J. R. Hume
Part of the NATO ASI Series book series (NSSA, volume 251)


The pulmonary vasculature is unique in that hypoxia causes vasoconstriction; whereas, most systemic vessels dilate (Daut et al., 1990). Hypoxic pulmonary vasoconstriction (HPV) serves as an adaptive mechanism by which blood flow is diverted from poorly ventilated to better ventilated regions of the lung to optimize ventilation/perfusion matching (Archer and Weir, 1989a; Cutaia and Rounds, 1990).


Pulmonary Artery Carotid Body Rest Membrane Potential Hypoxic Pulmonary Vasoconstriction Voltage Ramp 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. M. Post
    • 1
  • E. K. Weir
    • 2
  • S. L. Archer
    • 2
  • J. R. Hume
    • 1
  1. 1.Department of PhysiologyUniversity of Nevada School of MedicineRenoUSA
  2. 2.Department of MedicineUniversity of Minnesota, Minneapolis Veterans Administration Medical CenterMinneapolisUSA

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