Cardiac Contractions, PVA and Energetic Considerations Determined from a Cardiac Muscle Crossbridge Model
As computers become more and more powerful, mathematical modeling and computer simulation becomes increasingly more important. Some recent personal computer designs offer performance that was in the realm of super computers only a decade ago. This allows chemistry and physics to be implemented in the mathematical modeling solution of biochemical problems. With sophisticated computer solutions available, various biochemical hypotheses can be quickly investigated, and this can aid in the experimental design and fundamental understanding of biochemical phenomena.
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- 3(Supplement II).Goto, Y., S. Futaki, Y. Ohgoshi, H. Yaku and H. Suga. A new measure of left ventricular regional oxygen consumption: Systolic “tension-area”. Circulation 80: 154, 1989.Google Scholar
- 4.Huxley, A.F. Muscle structure and theories of contraction. Progr Biophys Biophys Chem 7:255–318, 1957.Google Scholar
- 5.Wong, A.Y.K. Mechanics of cardiac muscle, based on Huxley’s Model: mathematical simulation of isometric contraction. J Biochem 4:529–540, 1971.Google Scholar
- 6.Wong, A.Y.K. Mechanics of cardiac muscle, based on Huxley’s Model: simulation of active state and force-velocity relation. J Biochem 5:107–117, 1972.Google Scholar
- 7.Panerai, R.B. A model of cardiac muscle mechanics and energetics. J Biochem 13:929–940, 1980.Google Scholar
- 10.Taylor, T.W. et al. Comparison of the cardiac force-time integral with energetics using a cardiac muscle model. J Biochem 26:1217–1225, 1993.Google Scholar
- 17.Woledge, E. Energetic aspects of muscle contraction. Academic Press, London. Soc Monogr 41, 1985.Google Scholar
- 25.Gibbs, C.L. Cardiac energetics and the Fenn effect. In Cardiac Energetics: Basic Mechanism and Clinical Implications. Edited by Jacob, R., Just, J., and Holubarsch, C., New York, Springer Publishing Co., Inc., 61–68, 1987.Google Scholar