Adenosine A2 Receptor Regulation of Striatal Gene Expression

  • Serge N. Schiffmann
  • Jean-Jacques Vanderhaeghen


Any perturbations within the basal ganglia system lead to movement disorders [1]. The striatum, receiving its main input from the cerebral cortex, is the first relay of this system, and its medium-sized spiny neurons give rise to the output pathways. Two subpopulations of these efferent GABAergic neurons have been identified. The neurons projecting to the globus pallidus, striatopallidal, express enkephalin and mostly the dopamine D2 receptor, whereas the neurons projecting to the susbtantia nigra pars reticulata, striatonigral, express substance P, dynorphin, and the dopamine D1 receptor [2]. These two subpopulations give rise to different loops, acting respectively as an inhibitory and an excitatory pathway to the thalamus [1]. In addition, two classes of interneurons mostly represent the remaining striatal neurons: the cholinergic and the somatostatin-expressing neurons.


Dopamine Depletion Caffeine Treatment Dopaminergic Nigrostriatal Pathway Basal Ganglion System Striatopallidal Neuron 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Serge N. Schiffmann
  • Jean-Jacques Vanderhaeghen

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