Studies on the Mechanism by Which Adenosine Receptor Antagonists Attenuate Acute Renal Failure

  • Edwin K. Jackson
  • Zaichuan Mi
  • William A. Herzer


Acute renal failure (ARF) is an extremely serious medical condition characterized by an abrupt reduction in glomerular filtration rate (GFR), which leads to the retention of nitrogenous wastes. Five percent of all hospitalized patients develop acute renal failure, and the mortality rate in such patients is high [1]. Therefore, development of effective therapeutic strategies for ARF would be a significant medical advance.


Glomerular Filtration Rate Acute Renal Failure Renal Blood Flow Mean Arterial Blood Pressure Microdialysis Probe 
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  1. 1.
    Hou SH, Bushinsky DA, Wish JB, Cohen JJ, Harrington JT (1983) Hospital-acquired renal insufficiency: A prospective study. Am J Med 74:243–248.PubMedCrossRefGoogle Scholar
  2. 2.
    Lunding M, Steiness I, Thaysen JH (1964) Acute renal failure due to tubular necrosis. Immediate prognosis and complications. Acta Med Scand 176:103–119.PubMedCrossRefGoogle Scholar
  3. 3.
    Bidani AK, Churchill PC (1983) Aminophylline ameliorates glycerol-induced acute renal failure in rats. Can J Physiol Pharmacol 61: 567–571.PubMedCrossRefGoogle Scholar
  4. 4.
    Bowmer CJ, Collis MG, Yates MS (1986) Effect of the adenosine antagonist 8-phenyltheophylline on glycerol-induced acute renal failure in the rat. Br J Pharmacol 88:205–212.PubMedCrossRefGoogle Scholar
  5. 5.
    Bidani AK, Churchill PC, Packer W (1987) Theophylline-induced protection in myoglobinuric acute renal failure: Further characterization. Can J Physiol Pharmacol 65:42–45.PubMedCrossRefGoogle Scholar
  6. 6.
    Kellett R, Bowmer CJ, Collis MG, Yates MS (1989) Amelioration of glycerol-induced acute renal failure in the rat with 8-cyclopentyl-1, 3-dipropylxanthine. Br J Pharmacol 98: 1066–1074.PubMedCrossRefGoogle Scholar
  7. 7.
    Ishikawa I, Shikura N, Takada K (1993) Amelioration of glycerol-induced acute renal failure in rats by an adenosine A1 receptor antagonist (FR-113453). Ren Fail 15:1–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Shimada J, Suzuki F, Nonaka H, Karasawa A, Mizumoto H, Ohno T, Kubo K, Ishii A (1991) 8-(Dicyclopropylmethyl)-1, 3-dipropylxanthine: A potent and selective adenosine A1 antagonist with renal protective and diuretic activities. J Med Chem 34:466–469.PubMedCrossRefGoogle Scholar
  9. 9.
    Panjehshahin MR, Munsey TS, Collis MG, Bowmer CJ, Yates MS (1992) Further characterization of the protective effect of 8-cyclopentyl1, 3-dipropylxanthine on glycerol-induced acute renal failure in the rat. J Pharm Pharmacol 44:109–113.PubMedCrossRefGoogle Scholar
  10. 10.
    Suzuki F (1992): KW-3902. Drugs Fut 17: 876–878.Google Scholar
  11. 11.
    Andoh TF, Terai T, Nakano K, Horiai H, Mori J, Kohsaka M (1991) Protective effects of FR 113453, an adenosine A1-receptor antagonist, on experimental acute renal failure in rats. In International Symposium on Acute Renal Failure (October 2–4, 1991), University of North Carolina, Chapel Hill, NC.Google Scholar
  12. 12.
    Heidemann HT, Bolten M, Inselmann G (1991) Effect of chronic theophylline administration on amphotericin B nephrotoxicity in rats. Nephron 59:294–298.PubMedCrossRefGoogle Scholar
  13. 13.
    Lin JJ, Churchill PC, Bidani AK (1988) Theophylline in rats during maintenance phase of post-ischemic acute renal failure. Kidney Int 33:24–28.PubMedCrossRefGoogle Scholar
  14. 14.
    Heidemann HT, Muller S, Mertins L, Stepan G, Hoffmann K, Ohnhaus EE (1989) Effect of aminophylline on cisplatin nephrotoxicity in the rat. Br J Pharmacol 97:313–318.PubMedCrossRefGoogle Scholar
  15. 15.
    Knight RJ, Collis MG, Yates MS, Bowmer CJ (1991) Amelioration of cisplatin-induced acute renal failure with 8-cyclopentyl-1,3-dipropylxanthine. Br J Pharmacol 104:1062–1068.PubMedCrossRefGoogle Scholar
  16. 16.
    Lieberthal W, Levinsky NG (1992) Acute clinical renal failure. In Seldin DW, Giebisch G (eds.), The Kidney: Physiology and Pathophysiology, 2nd ed. New York: Raven Press, pp. 3181–3225.Google Scholar
  17. 17.
    Beck F, Thurau K, Gstraunthaler G (1992) Pathophysiology and pathobiochemistry of acute renal failure. In Seldin DW, Giebisch G (eds.), The Kidney: Physiology and Pathophysiology, 2nd ed. New York: Raven Press, pp. 3157–3225.Google Scholar
  18. 18.
    Osswald H, Hermes HH, Nabakowski G (1982) Role of adenosine in signal transmission of tubuloglomerular feedback. Kidney Int Suppl 12:S136–S142.PubMedGoogle Scholar
  19. 19.
    Schnermann J, Weihprecht H, Briggs JP (1990) Inhibition of tubuloglomerular feedback during adenosine1 receptor blockade. Am J Physiol 258:F553–F561.PubMedGoogle Scholar
  20. 20.
    Franco M, Bell PD, Navar LG (1989) Effect of adenosine A1 analogue on tubuloglomerular feedback mechanism. Am J Physiol 257: F231–F236.PubMedGoogle Scholar
  21. 21.
    Murray RD, Churchill PC (1985) Concentration dependency of the renal vascular and renie secretory responses to adenosine receptor agonists. J Pharmacol Exp Ther 232:189–193.PubMedGoogle Scholar
  22. 22.
    Nies AS, Beckmann ML, Gerber JG (1991) Contrasting effects of changes in salt balance on the renovascular response to A1-adenosine receptor stimulation in vivo and in vitro in the rat. J Pharmacol Exp Ther 256:542–546.PubMedGoogle Scholar
  23. 23.
    Inscho EW, Carmins PK, Navar LG (1991) Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation. Hypertension 17:1033–1037.PubMedCrossRefGoogle Scholar
  24. 24.
    Barrett RJ, Droppleman DA (1993) Interactions of adenosine A1 receptor-mediated renal vasoconstriction with endogenous nitric oxide and ANG II. Am J Physiol 265:F651–F659.PubMedGoogle Scholar
  25. 25.
    Yagil Y (1994) The effects of adenosine on water and sodium excretion. J Pharmacol Exp Ther 268:826–835.PubMedGoogle Scholar
  26. 26.
    Kuan CJ, Herzer WA, Jackson EK (1992) An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo. J Pharmacol Exp Ther 263:657–662.PubMedGoogle Scholar
  27. 27.
    Mi Z, Herzer WA, Zhang Y, Jackson EK (1994) 3-Isobutyl-1-methylxauthine decreases renal cortical interstitial levels of adenosine and inosine. Life Sci 54:PL277–PL282.CrossRefGoogle Scholar
  28. 28.
    Agmon Y, Dinour D, Brezis M (1993) Disparate effects of adenosine A1- and A2-receptor agonists on intrarenal blood flow. Am J Physiol 265: F802 - F806.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Edwin K. Jackson
  • Zaichuan Mi
  • William A. Herzer

There are no affiliations available

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