Abstract
The contribution of polymorphonuclear neutrophilic granulocytes (PMN) to acute postischemic reperfusion damage in the heart is a controversial issue but, due to their being equipped with proteolytic enzymes and potent mechanisms for generating reactive oxygen species, these cells certainly have the potential to rapidly cause functional derangement. In experiments conducted on isolated perfused hearts of the guinea pig, PMN of both guinea pig or human origin were able to significantly suppress the pumping ability after ischemia by 50% when applied in small numbers (2-40 million cells) [1,2]. Antioxidants protected from this cardiodepressant action, and the PMN effect was dependent on prior myocardial ischemia [1].
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References
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Becker, B.F., Zahler, S., Richardt, G. (1995). Endothelial Adenosine Receptors Modulate Leukocyte Adhesion: Relevance for Myocardial Reperfusion Damage. In: Belardinelli, L., Pelleg, A. (eds) Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2011-5_42
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DOI: https://doi.org/10.1007/978-1-4615-2011-5_42
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