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Myocardial Adenosine Receptors

  • Cynthia Kollias-Baker
  • John C. Shryock
  • Luiz Belardinelli

Abstract

Currently there are four well-defined subclasses of adenosine receptors, namely, A1, A2a, A2b, and A3. In the heart, A1 receptor pharmacology, regulation, and coupling to functional responses have been well characterized. The presence of an A2 receptor that mediates adenosine-induced coronary vasodilation is also well established, although the receptor subtype (A2a vs. A2b) is still the subject of some debate. The A2 receptor and its role in adenosine-mediated coronary vasodilation are reviewed in Chapter 27. Although the results of several studies provide support for the presence of an A3 receptor in the heart, a physiologic role for the cardiac A3 receptor has yet to be determined. Thus, the primary focus of this review will be the cardiac A1 adenosine receptor; however physical or functional evidence for the presence of other receptor subtypes on cardiomyocytes will be presented.

Keywords

Adenosine Receptor Ventricular Myocytes Adenosine Receptor Subtype Allosteric Enhancer Guanine Nucleotide Regulatory Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Belardinelli L, Linden J, Berne RM (1989) The cardiac effects of adenosine. Prog Cardiovasc Dis 32:73–97.PubMedCrossRefGoogle Scholar
  2. 2.
    Schrader J, Baumann G, Gerlach E (1977) Adenosine as inhibitor of myocardial effects of catecholamines. Pflügers Arch 372:29–35.PubMedCrossRefGoogle Scholar
  3. 3.
    Shryock JC, Patel A, Belardinelli L, Linden J (1989) Down regulation and desensitization of A1-adenosine receptors in embryonic chicken heart. Am J Physiol 256:H321—H327.PubMedGoogle Scholar
  4. 4.
    Wu S-N, Linden J, Visentin S, Boykin M, Belardinelli L (1989) Enhanced sensitivity of heart cells to adenosine and upregulation of receptor number after treatment of guinea pigs with theophylline. Circ Res 65:1066–1077.PubMedCrossRefGoogle Scholar
  5. 5.
    Liang BT, Donovan LA (1990) Differential desensitization of A1 adenosine receptor-mediated inhibition of cardiac myocyte contractility and adenylate cyclase activity. Circ Res 67:406–414.PubMedCrossRefGoogle Scholar
  6. 6.
    Lee HT, Thompson CI, Linden J, Belloni FL (1993) Differential sensitization of cardiac actions of adenosine in rats following chronic theophylline treatment. Am J Physiol 264: H1634—H1643.PubMedGoogle Scholar
  7. 7.
    Lee HT, Thompson CI, Hernandez A, Lewy JL, Belloni FL (1993) Cardiac desensitization to adenosine analogues after prolonged R-PIA infusion in vivo. Am J Physiol 265: H1916—H1927.PubMedGoogle Scholar
  8. 8.
    Bruns RF, Fergus JH (1990) Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Mol Pharmacol 38:939–949.PubMedGoogle Scholar
  9. 9.
    Amoah-Apraku B, Xu J, Lu JY, Pelleg A, Bruns RF, Belardinelli L (1993) Selective potentiation by an A1 adenosine selective enhancer of the negative dromotropic action of adenosine in the guinea heart. J Pharmacol Exp Ther 266:611–617.PubMedGoogle Scholar
  10. 10.
    Mudumbi RV, Montamat SC, Bruns RF, Vestal RE (1993) Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. Am J Physiol 264: H1017–H1498.PubMedGoogle Scholar
  11. 11.
    Kollias-Baker C, Ruble J, Belardinelli L (1994) Mechanisms of allosteric enhancement of agonist binding to the A1 adenosine receptor (abstr). Drug Dev Res 31:286.Google Scholar
  12. 12.
    Kollias-Baker C, Belardinelli (1994) Allosteric enhancer of the A1 adenosine receptor markedly increases AV nodal conduction delay during hypoxia in guinea pig hearts (abstr). Drug Dev Res 31:287.Google Scholar
  13. 13.
    Ellenbogen KA, Thames MD, DiMarco JP, Sheehan H, Lerman BB (1990) Electrophysiological effects of adenosine in the transplanted human heart. Evidence for supersensitivity. Circulation 81:821–828.PubMedCrossRefGoogle Scholar
  14. 14.
    Musser B, Morgan ME, Leid M, Murray TF, Linden J, Vestal RE (1993) Species cornparison of adenosine and beta-adrenoceptors in mammalian atrial and ventricular myocardium. Eur J Pharmacol-Mol Pharmacol Sec 246:105–111.CrossRefGoogle Scholar
  15. 15.
    Martens D, Lohse MJ, Schwabe U (1988) {3H{8-Cyclopentyl- 1, 3-dipropylxanthine binding to A1 adenosine receptors of intact rat ventricular myocytes. Circ Res 63:613–620.PubMedCrossRefGoogle Scholar
  16. 16.
    Bohm M, Pieske B, Ungerer M, Erdmann E (1989) Characteristics of A1 adenosine receptors in atrial and ventricular myocardium from diseased human hearts. Circ Res 65:1201–1211.PubMedCrossRefGoogle Scholar
  17. 17.
    Linden J, Patel A, Sadek S (1985) 125IAminobenzyladenosine, a new radioligand with improved specific binding to adenosine receptors in heart. Circ Res 56:279–284.PubMedCrossRefGoogle Scholar
  18. 18.
    Froldi G, Belardinelli L (1990) Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications. Circ Res 67: 960–978.PubMedCrossRefGoogle Scholar
  19. 19.
    Yeung SMH, Green RD (1983) Agonist and antagonist affinities for inhibitory adenosine receptors are reciprocally affected by 5’-guanylylimidodiphosphate or N- ethylmaleimide. J Biol Chem 258:2334–2339.PubMedGoogle Scholar
  20. 20.
    Stiles GL, Daly DT, Olsson RA (1986) Characterization of the A1 adenosine receptoradenylate cyclase system of cerebral cortex using an agonist photoaffinity probe. J Neurochem 47:1020–1025.PubMedCrossRefGoogle Scholar
  21. 21.
    Jacobson KA, van Galen PJM, Ji X-D, Ramkumar V, Olah ME, Stiles GL (1993) Molecular characterization of A1 and A2a adenosine receptors. Drug Dev Res 28:226–231.PubMedCrossRefGoogle Scholar
  22. 22.
    Stehle JH, Rivkees SA, Lee JJ, Weaver DR, Deeds JD, Reppert SM (1992) Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol 6:384–393.PubMedCrossRefGoogle Scholar
  23. 23.
    Xu D, Kong HY, Liang BT (1992) Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes. Circ Res 70: 56–65.PubMedCrossRefGoogle Scholar
  24. 24.
    Olsson RA, Pearson JD (1990) Cardiovascular purinoceptors. Physiol Rev 70:761–845.PubMedGoogle Scholar
  25. 25.
    Huang M, Drummond GI (1976) Effect of adenosine on cyclic AMP accumulation in ventricular myocardium. Biochem Pharmacol 25:2713–2719.PubMedCrossRefGoogle Scholar
  26. 26.
    Webster S, Olsson RA (1981) Adenosine regulation of canine cardiac adenylate cyclase. Biochem Pharmacol 30:369–373.PubMedCrossRefGoogle Scholar
  27. 27.
    Anand-Srivastava MB, Cantin M (1983) Regulation of adenylate cyclase in cultured cardiomyocytes from neonatal rats by adenosine and other agonists. Arch Biochem Biophys 223: 468–476.PubMedCrossRefGoogle Scholar
  28. 28.
    Bruckner R, Fenner A, Meyer W, Nobis TM, Schmitz W, Scholz H (1985) Cardiac effects of adenosine and adenosine analogs in guinea pig atrial and ventricular preparations: Evidence against a role of cyclic AMP and cyclic GMP. J Pharmacol Exp Ther 234:766–774.PubMedGoogle Scholar
  29. 29.
    Romano FD, Macdonald SG, Dobson JG (1989) Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes. Am J Physiol 257:H1088–H1095.PubMedGoogle Scholar
  30. 30.
    Stein B, Schmitz W, Scholz H, Seeland C (1994) Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes. J Mol Cell Cardiol 26:403–414.PubMedCrossRefGoogle Scholar
  31. 31.
    Shryock J, Song Y, Wang D, Baker SD, Olsson R, Belardinelli L (1993) Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. Circ Res 72: 194–205.PubMedCrossRefGoogle Scholar
  32. 32.
    Ribeiro JA, Sebastiao AM (1986) Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor. Prog Neurobiol 26:179–209.PubMedCrossRefGoogle Scholar
  33. 33.
    Carruthers AM, Fozard JR (1993) Adenosine A3 receptors: Two into one won’t go. Trends Pharmacol Sci 14:290–291.PubMedCrossRefGoogle Scholar
  34. 34.
    Zhou QY, Li C, Olah ME, Johnson RA, Stiles GL, Civelli O (1992) Molecular cloning and characterization of an adenosine receptor: The A3 adenosine receptor. Proc Natl Acad Sci 89: 7432–7436.PubMedCrossRefGoogle Scholar
  35. 35.
    Meyerhof W, Muller-Brechlin R, Richter D (1991) Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Lett 284:155–160.PubMedCrossRefGoogle Scholar
  36. 36.
    Linden J, Taylor HE, Robeva AS, Tucker AL, Stehle JH, Rivkees SA, Fink JS, Reppert SM (1993) Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Mol Pharmacol 44:524–532.PubMedGoogle Scholar
  37. 37.
    Salvatore CA, Jacobson MA, Taylor HA, Linden J, Johnson RG (1993) Molecular cloning and characterization of the human A3 adenosine receptor. Proc Nati Acad Sci USA 90:10365–10369.CrossRefGoogle Scholar
  38. 38.
    Sajjadi FG, Firestein GS (1993) cDNA cloning and sequence analysis of the human A3 adenosine receptor. Biochim Biophys Acta 1179:105–107.PubMedCrossRefGoogle Scholar
  39. 39.
    Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G (1989) Selective amplification of four new members of the G protein-coupled receptor family. Science 244:569–572.PubMedCrossRefGoogle Scholar
  40. 40.
    Jacobson M (1994) Cloning and expression of human adenosine receptor subtypes (abstr). Drug Dev Res 31:281.Google Scholar
  41. 41.
    Tucker AL, Linden J (1993) Cloned receptors and cardiovascular responses to adenosine. Cardiovasc Res 27:62–67.CrossRefGoogle Scholar
  42. 42.
    Ungerer M, Obermaier-Skrobranek B, Lohse MJ (1992) Cloning and expression of a cardiac A1 adenosine receptor from normotensive and spontaneously hypertensive rats (abstr). Circulation 86:I-304.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Cynthia Kollias-Baker
  • John C. Shryock
  • Luiz Belardinelli

There are no affiliations available

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