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Molecular Biology of Adenosine Receptors

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Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

Abstract

Prior to the application of recombinant DNA technology, the characterization of adenosine receptor subtypes was limited to information obtained from classic pharmacological analysis. Through the use of gene cloning and molecular biologic techniques, we have significantly advanced our understanding of the number of adenosine receptor subtypes and their molecular characteristics, such as primary sequence, structural homology between species, pharmacologic profiles of agonists and antagonists, and distribution of tissue and cellular expression. Molecular cloning has confirmed the existence of three adenosine receptor subtypes predicted from affinity order profiles of agonists and antagonists, and coupling to adenylyl cyclase, and, in addition, has identified a fourth subtype that had previously remained pharmacologically undetected. In this overview progress in the cloning and molecular characterization of adenosine receptors will be summarized.

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Authors
  1. Marlene A. Jacobson
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Editors and Affiliations

  1. University of Florida, USA

    Luiz Belardinelli

  2. Hahnemann University, USA

    Amir Pelleg

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© 1995 Springer Science+Business Media New York

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Jacobson, M.A. (1995). Molecular Biology of Adenosine Receptors. In: Belardinelli, L., Pelleg, A. (eds) Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2011-5_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2011-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5831-2

  • Online ISBN: 978-1-4615-2011-5

  • eBook Packages: Springer Book Archive

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