Fluoropyrimidine catabolism

  • Robert B. Diasio
  • Zhihong Lu
  • Ruiwen Zhang
  • Harout S. Shahinian
Part of the Cancer Treatment and Research book series (CTAR, volume 78)


Antimetabolites are a class of chemotherapeutic agents that have a chemical structure similar to physiologic intermediates and can function as substrates for important enzymatic reactions required in vital cell biologic processes, e.g., synthesis of DNA and RNA. Several reviews on the metabolism of antimetabolite drugs have recently been published, providing a general background on these drugs [1–5]. The pyrimidine antimetabolite drugs consist of base or nucleoside analogues of the naturally occurring pyrimidines, i.e., uracil, thymine, and cytosine. They have a strong structural similarity to these endogenous nucleic acid precursors, with structural differences including substitutions at one of the carbons in the pyrimidine ring or one of the hydrogens attached to the ring of the pyrimidine or sugar (ribose or deoxyribose).


Thymidine Kinase Circadian Variation Dihydropyrimidine Dehydrogenase Peripheral Blood Mononuclear Thymidine Kinase Activity 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Robert B. Diasio
  • Zhihong Lu
  • Ruiwen Zhang
  • Harout S. Shahinian

There are no affiliations available

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