Regulation of Macrophage Activation and HIV Replication

  • Luis J. Montaner
  • Georges Herbein
  • Siamon Gordon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 374)

Abstract

In normal immune responses, macrophages play a key role in the host’s defence system combating disease, clearing foreign antigens and protecting against invading microrganisms. The ability of the macrophage (mØ) to mediate effective immune responses is associated with its capacity to respond and control its activation upon encountering the appropriate exogenous or endogenous signal. Activation is defined by the stimulus which changes or predisposes to changes in cellular activity, while activation potential is the ability to undergo activation. Since immune activation involves all aspects of immunological responses, we will differentiate between two general types of cytokine-orientated activation when discussing macrophages: pro-inflammatory and immuno-regulatory. Pro-inflammatory activation refers to the state of immunological “alarm” mediated by TNF-α, IL-1β, IL-6 and chemokines, while immuno-regulatory activation refers to responses mediated by IFNs, IL-2, IL-4, IL-10, IL-12, and IL-13. Although discussed separately, these types of activation are not mutually exclusive and seldom occur in isolation.

Keywords

Migration Hydrogen Peroxide Dementia Superoxide Sarcoma 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Luis J. Montaner
    • 1
  • Georges Herbein
    • 2
  • Siamon Gordon
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK
  2. 2.Institute of Virology and INSERM U74Louis Pasteur UniversityStrasbourgFrance

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