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Molecular Basis of Cell Cycle Dependent HIV-1 Replication

Implications for Control of Virus Burden

  • Chapter
Book cover Cell Activation and Apoptosis in HIV Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 374))

Abstract

Retroviruses show a strong cell cycle dependence for productive infection. For example, the onco-retrovirus murine leukaemia virus (MLV) requires proliferating host cells for productive infection (Temin, 1988; Varmus and Brown, 1989). This restriction appears to reflect an inability of viral DNA to localize to the host cell nucleus until the host cell enters mitosis (Roe, et al., 1993; Lewis, 1994 and Emerman, 1994). This dependence of onco-retroviruses for dividing cells is further illustrated by the poor transduction capacities of onco-retrovirus based retroviral vectors in non-dividing cell systems in vitro (miller, et al., 1990; Springett, et al., 1989).

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Authors and Affiliations

  1. Department of Pathology and Microbiology, USA

    M. Stevenson, B. Brichacek, N. Heinzinger & S. Pirruccello

  2. Department of Internal Medicine, USA

    S. Swindells

  3. Eppley Institute for Research in Cancer and Related Diseases, University of Nebraska Medical Center, Omaha, Nebraska, 68198-5120, USA

    M. Stevenson

  4. VA Medial Center, Minneapolis, Minnesota, 55417, USA

    E. Janoff

  5. Basic Sciences Division, M774, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98194, USA

    M. Emerman

Authors
  1. M. Stevenson
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  2. B. Brichacek
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  3. N. Heinzinger
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  4. S. Swindells
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  5. S. Pirruccello
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  6. E. Janoff
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  7. M. Emerman
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Editors and Affiliations

  1. Laennec Hospital, Paris, France

    Jean-Marie Andrieu  & Wei Lu  & 

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Stevenson, M. et al. (1995). Molecular Basis of Cell Cycle Dependent HIV-1 Replication. In: Andrieu, JM., Lu, W. (eds) Cell Activation and Apoptosis in HIV Infection. Advances in Experimental Medicine and Biology, vol 374. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1995-9_4

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  • DOI: https://doi.org/10.1007/978-1-4615-1995-9_4

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-1995-9

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